Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A4 Analogues

被引：48

作者：

Duffy, Colm D. ^{[1
]}

Maderna, Paola ^{[2
]}

McCarthy, Ciara ^{[3
]}

Loscher, Christine E. ^{[3
]}

Godson, Catherine ^{[2
]}

Guiry, Patrick J. ^{[1
]}

机构：

[1] Univ Coll Dublin, UCD Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland

[2] Univ Coll Dublin, UCD Sch Med & Med Sci, Conway Inst Biomol & Biomed Res, UCD Diabet Res Ctr, Dublin 4, Ireland

[3] Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 04期

基金：

爱尔兰科学基金会;

关键词：

cytokines; eicosanoids; inflammation; lipoxins; synthesis design; ARACHIDONIC-ACID; POTENT; EFFICIENT; RECEPTOR; MEDIATORS; CATALYST; SERIES;

D O I：

10.1002/cmdc.200900533

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A short and efficient synthesis of new pyridine-containing lipoxin A4 analogues was developed. These analogues induce phagocytosis of apoptotic polymorphonuclear leukocytes and display antiinflammatory characteristics by suppressing pro-inflammatory cytokine production by macrophages. © 2010 Wiley-VCH Verlag GmbHand Co. KGaA, Weinheim.

引用

页码：517 / 522

页数：6

共 33 条

[31]

Williams D. A., 2002, FOYES PRINCIPLES MED, P60

[32] Signal pathway involved in inhibition by lipoxin A4 of production of interleukins induced in endothelial cells by lipopolysaccharide [J].

Wu, S. -H. ;

Liao, P. -Y. ;

Dong, L. ;

Chen, Z. -Q. .

INFLAMMATION RESEARCH, 2008, 57 (09) :430-437

[33] 5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for α4β2 nicotinic acetylcholine receptor and wide range of lipophilicity:: Potential probes for imaging with positron emission tomography [J].

Zhang, Y ;

Pavlova, OA ;

Chefer, SI ;

Hall, AW ;

Kurian, V ;

Brown, LL ;

Kimes, AS ;

Mukhin, AG ;

Horti, AG .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (10) :2453-2465

← 1 2 3 4 →