Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A4 Analogues

被引：48

作者：

Duffy, Colm D. ^{[1
]}

Maderna, Paola ^{[2
]}

McCarthy, Ciara ^{[3
]}

Loscher, Christine E. ^{[3
]}

Godson, Catherine ^{[2
]}

Guiry, Patrick J. ^{[1
]}

机构：

[1] Univ Coll Dublin, UCD Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland

[2] Univ Coll Dublin, UCD Sch Med & Med Sci, Conway Inst Biomol & Biomed Res, UCD Diabet Res Ctr, Dublin 4, Ireland

[3] Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 04期

基金：

爱尔兰科学基金会;

关键词：

cytokines; eicosanoids; inflammation; lipoxins; synthesis design; ARACHIDONIC-ACID; POTENT; EFFICIENT; RECEPTOR; MEDIATORS; CATALYST; SERIES;

D O I：

10.1002/cmdc.200900533

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A short and efficient synthesis of new pyridine-containing lipoxin A4 analogues was developed. These analogues induce phagocytosis of apoptotic polymorphonuclear leukocytes and display antiinflammatory characteristics by suppressing pro-inflammatory cytokine production by macrophages. © 2010 Wiley-VCH Verlag GmbHand Co. KGaA, Weinheim.

引用

页码：517 / 522

页数：6

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