Clinical features and outcomes of young patients with head and neck non-rhabdomyosarcoma soft tissue sarcomas

被引：7
作者：
Federico, Sara M. [1 ,3 ]
Gilpin, David [1 ]
Samant, Sandeep [4 ]
Billups, Catherine A. [2 ]
Spunt, Sheri L. [1 ,3 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Biostat, Memphis, TN 38105 USA
[3] Univ Tennessee, Coll Med, Dept Pediat, Memphis, TN USA
[4] Univ Tennessee, Ctr Hlth Sci, Dept Otolaryngol Head & Neck Surg, Memphis, TN 38163 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2015年 / 37卷 / 01期
关键词：
head and neck; soft tissue sarcoma; pediatrics; non-rhabdomyosarcoma soft tissue sarcoma (NRSTS); GASTROINTESTINAL STROMAL TUMORS; LIMB-SPARING SURGERY; PROGNOSTIC-FACTORS; RADIATION-THERAPY; NEOADJUVANT CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; NONRHABDOMYOSARCOMA; EXTREMITY; CHILDREN; ADULT;
D O I：
10.1002/hed.23564
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundThe history, prognostic factors, and outcome of young patients with head and neck non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) have not been adequately characterized. MethodsMedical records of 58 patients with head and neck NRSTS treated at St. Jude Children's Research Hospital were reviewed. ResultsThe majority of tumors were 5 cm and high grade. Lymph node and/or distant metastases were present in 17% at presentation. Patients received a combination of surgery, chemotherapy, and radiotherapy. The 10-year event-free and survival rates were 53.1%7.3% and 63.2%+/- 7.1%, respectively. Features associated with inferior survival included high histologic grade (p=.006), tumor diameter >5 cm (p < .001), invasiveness (p < .001), and incomplete resection at diagnosis (p=.005). ConclusionMost head and neck NRSTS in young patients are small, high grade, and nonmetastatic. The outcome is poor compared to NRSTS at other anatomic sites. Innovative approaches to local control and improved systemic therapy are needed. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 76-83, 2015
引用
收藏
页码：76 / 83
页数：8
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