Dendritic Cell-Based Vaccine for the Treatment of Malignant Glioma: A Systematic Review

被引：38
作者：
Wang, Xuan [1 ]
Zhao, Hong-Yang [1 ]
Zhang, Fang-Cheng [1 ]
Sun, Yun [1 ]
Xiong, Zhi-Yong [1 ]
Jiang, Xiao-Bing [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan 430022, Peoples R China
来源：
CANCER INVESTIGATION | 2014年 / 32卷 / 09期
关键词：
Glioblastoma multiforme; Dendritic cell vaccination; Immunotherapy; Survival; CONVECTION-ENHANCED DELIVERY; T-CELL; IMMUNOTHERAPY; THERAPY; TRIAL; TEMOZOLOMIDE; STANDARD; SURVIVAL; TUMORS; AGE;
D O I：
10.3109/07357907.2014.958234
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: Glioblastoma multiforme (GBM) has a poor prognosis. The purpose of this systematic review and meta-analysis was to analyze the outcomes of clinical trials which compared immunotherapy with conventional therapy for the treatment of malignant gliomas. Methods: PubMed, Cochrane and Google Scholar databases were searched for relevant studies. The 2-year survival rate was used to evaluate effectiveness of immunotherapy. Results: Of 171 studies identified, six comparative trials were included in the systematic review. Immunotherapy was associated with a significantly longer OS and 2-year survival compared to conventional therapy. Conclusion: Immunotherapy may improve the survival of patients with GBM.
引用
收藏
页码：451 / 457
页数：7
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