Dendritic Cell-Based Vaccine for the Treatment of Malignant Glioma: A Systematic Review

被引：36

作者：

Wang, Xuan ^{[1
]}

Zhao, Hong-Yang ^{[1
]}

Zhang, Fang-Cheng ^{[1
]}

Sun, Yun ^{[1
]}

Xiong, Zhi-Yong ^{[1
]}

Jiang, Xiao-Bing ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan 430022, Peoples R China

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 09期

关键词：

Glioblastoma multiforme; Dendritic cell vaccination; Immunotherapy; Survival; CONVECTION-ENHANCED DELIVERY; T-CELL; IMMUNOTHERAPY; THERAPY; TRIAL; TEMOZOLOMIDE; STANDARD; SURVIVAL; TUMORS; AGE;

D O I：

10.3109/07357907.2014.958234

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: Glioblastoma multiforme (GBM) has a poor prognosis. The purpose of this systematic review and meta-analysis was to analyze the outcomes of clinical trials which compared immunotherapy with conventional therapy for the treatment of malignant gliomas. Methods: PubMed, Cochrane and Google Scholar databases were searched for relevant studies. The 2-year survival rate was used to evaluate effectiveness of immunotherapy. Results: Of 171 studies identified, six comparative trials were included in the systematic review. Immunotherapy was associated with a significantly longer OS and 2-year survival compared to conventional therapy. Conclusion: Immunotherapy may improve the survival of patients with GBM.

引用

页码：451 / 457

页数：7

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