Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury

被引：13

作者：

Li, Yuting ^{[1
]}

Sun, Yuhua ^{[1
,2
]}

Cai, Min ^{[1
]}

Zhang, Huanhuan ^{[1
]}

Gao, Nannan ^{[1
]}

Huang, Huiwei ^{[3
]}

Cui, Shusen ^{[4
]}

Yao, Dengbing ^{[1
]}

机构：

[1] Nantong Univ, Coinnovat Ctr Neuroregenerat, Sch Life Sci, Jiangsu Key Lab Neuroregenerat, Nantong, Peoples R China

[2] Lianyungang Maternal & Child Hlth Hosp, Genet Lab, Lianyungang, Peoples R China

[3] Nantong Univ, Sch Med, Nantong, Peoples R China

[4] Jilin Univ, China Japan Union Hosp, Hand Surg, Changchun, Jilin, Peoples R China

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2018年 / 11卷

基金：

中国国家自然科学基金;

关键词：

Wallerian degeneration; sciatic nerve injury; Fas ligand gene (Faslg); rat; nerve regeneration; Schwann cell; EARLY WALLERIAN DEGENERATION; REL/NF-KAPPA-B; PERIPHERAL-NERVE; SCHWANN-CELLS; TNF-ALPHA; EXPRESSION; RECEPTOR; APOPTOSIS; REPAIR; DEATH;

D O I：

10.3389/fnmol.2018.00210

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Wallerian degeneration (WD) is associated with changes in the expression levels of a large number of genes. However, the effects of these up- or down-regulated genes are poorly understood. We have reported some key factors that are differentially regulated during WD in our previous research. Here, we explored the roles of Fas ligand gene (Faslg) in WD after rat sciatic nerve injury. The data showed that Faslg was up-regulated in injured nerves. Expression changed of Faslg in Schwann cells (SCs) resulted in alterations in the release of related factors. Silencing or overexpression of Faslg affected SC proliferation, migration, and apoptosis through beta-catenin, nuclear factor-kappa B (NF-kappa B), and caspase-3 pathways in vivo and in vitro. Our data suggest that Faslg is a key regulatory gene that affects nerve repair and regeneration in peripheral nerve injury. This study sheds new light on the effects of Faslg on peripheral nerve degeneration and/or regeneration.

引用

页数：13

共 55 条

[11] Toll-Like Receptor Expression in the Peripheral Nerve [J].

Goethals, Sofie ;

Ydens, Elke ;

Timmerman, Vincent ;

Janssens, Sophie .

GLIA, 2010, 58 (14) :1701-1709

[12] The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury [J].

Gong, Leilei ;

Zhu, Yun ;

Xu, Xi ;

Li, Huaiqin ;

Guo, Weimin ;

Zhao, Qin ;

Yao, Dengbing .

NEURAL REGENERATION RESEARCH, 2014, 9 (24) :2151-2158

[13] Measuring nerve regeneration in the mouse [J].

Griffin, John W. ;

Pan, BaoHan ;

Polley, Michelle A. ;

Hoffman, Paul N. ;

Farah, Mohamed H. .

EXPERIMENTAL NEUROLOGY, 2010, 223 (01) :60-71

[14] Loss and recovery of the blood-nerve barrier in the rat sciatic nerve after crush injury are associated with expression of intercellular junctional proteins [J].

Hirakawa, H ;

Okajima, S ;

Nagaoka, T ;

Takamatsu, T ;

Oyamada, M .

EXPERIMENTAL CELL RESEARCH, 2003, 284 (02) :196-210

[15]

Idriss HT, 2000, MICROSC RES TECHNIQ, V50, P184, DOI 10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO

[16]

2-H

[17] The repair Schwann cell and its function in regenerating nerves [J].

Jessen, K. R. ;

Mirsky, R. .

JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (13) :3521-3531

[18] Schwann Cells: Development and Role in Nerve Repair [J].

Jessen, Kristjan R. ;

Mirsky, Rhona ;

Lloyd, Alison C. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2015, 7 (07) :1-15

[19] Comprehensive Evaluation of Peripheral Nerve Regeneration in the Acute Healing Phase Using Tissue Clearing and Optical Microscopy in a Rodent Model [J].

Jung, Yookyung ;

Ng, Joanna H. ;

Keating, Cameron P. ;

Senthil-Kumar, Prabhu ;

Zhao, Jie ;

Randolph, Mark A. ;

Winograd, Jonathan M. ;

Evans, Conor L. .

PLOS ONE, 2014, 9 (04)

[20] Peripheral nerve injuries: A retrospective survey of 456 cases [J].

Kouyoumdjian, Joao Aris .

MUSCLE & NERVE, 2006, 34 (06) :785-788

← 1 2 3 4 5 6 →