Fas Ligand Gene (Faslg) Plays an Important Role in Nerve Degeneration and Regeneration After Rat Sciatic Nerve Injury

被引：13
作者：
Li, Yuting [1 ]
Sun, Yuhua [1 ,2 ]
Cai, Min [1 ]
Zhang, Huanhuan [1 ]
Gao, Nannan [1 ]
Huang, Huiwei [3 ]
Cui, Shusen [4 ]
Yao, Dengbing [1 ]
机构：
[1] Nantong Univ, Coinnovat Ctr Neuroregenerat, Sch Life Sci, Jiangsu Key Lab Neuroregenerat, Nantong, Peoples R China
[2] Lianyungang Maternal & Child Hlth Hosp, Genet Lab, Lianyungang, Peoples R China
[3] Nantong Univ, Sch Med, Nantong, Peoples R China
[4] Jilin Univ, China Japan Union Hosp, Hand Surg, Changchun, Jilin, Peoples R China
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2018年 / 11卷
基金：
中国国家自然科学基金;
关键词：
Wallerian degeneration; sciatic nerve injury; Fas ligand gene (Faslg); rat; nerve regeneration; Schwann cell; EARLY WALLERIAN DEGENERATION; REL/NF-KAPPA-B; PERIPHERAL-NERVE; SCHWANN-CELLS; TNF-ALPHA; EXPRESSION; RECEPTOR; APOPTOSIS; REPAIR; DEATH;
D O I：
10.3389/fnmol.2018.00210
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Wallerian degeneration (WD) is associated with changes in the expression levels of a large number of genes. However, the effects of these up- or down-regulated genes are poorly understood. We have reported some key factors that are differentially regulated during WD in our previous research. Here, we explored the roles of Fas ligand gene (Faslg) in WD after rat sciatic nerve injury. The data showed that Faslg was up-regulated in injured nerves. Expression changed of Faslg in Schwann cells (SCs) resulted in alterations in the release of related factors. Silencing or overexpression of Faslg affected SC proliferation, migration, and apoptosis through beta-catenin, nuclear factor-kappa B (NF-kappa B), and caspase-3 pathways in vivo and in vitro. Our data suggest that Faslg is a key regulatory gene that affects nerve repair and regeneration in peripheral nerve injury. This study sheds new light on the effects of Faslg on peripheral nerve degeneration and/or regeneration.
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页数：13
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