Helminth-derived immunomodulators: can understanding the worm produce the pill?

被引：141

作者：

Harnett, William ^{[1
]}

Harnett, Margaret M. ^{[2
]}

机构：

[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland

[2] Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow G12 8TA, Lanark, Scotland

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金; 英国医学研究理事会;

关键词：

DENDRITIC CELL ACTIVATION; CONTAINING SECRETED PRODUCT; HOST IMMUNE-RESPONSES; DRIVES TH2 RESPONSES; TOLL-LIKE RECEPTORS; C-TYPE LECTINS; PROTEIN-KINASE; CUTTING EDGE; IN-VIVO; INFLAMMATORY RESPONSES;

D O I：

10.1038/nri2730

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helminths may protect humans against allergic and autoimmune diseases and, indeed, defined helminth-derived products have recently been shown to prevent the development of such inflammatory diseases in mouse models. Here, we propose that helminth-derived products not only have therapeutic potential but can also be used as unique tools for defining key molecular events in the induction of an anti-inflammatory response and, therefore, for defining new therapeutic targets.

引用

页码：278 / 284

页数：7

共 78 条

[1] Cutting edge: Different toll-like receptor agonists instruct dendritic cells to induce distinct th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-fos [J].

Agrawal, S ;

Agrawal, A ;

Doughty, B ;

Gerwitz, A ;

Blenis, J ;

Van Dyke, T ;

Pulendran, B .

JOURNAL OF IMMUNOLOGY, 2003, 171 (10) :4984-4989

[2] Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells [J].

Aksoy, E ;

Zouain, CS ;

Vanhoutte, F ;

Fontaine, J ;

Pavelka, N ;

Thieblemont, N ;

Willems, F ;

Ricciardi-Castagnoli, P ;

Goldman, M ;

Capron, M ;

Ryffel, B ;

Trottein, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (01) :277-283

[3] Protective immune mechanisms in helminth infection [J].

Anthony, Robert M. ;

Rutitzky, Laura I. ;

Urban, Joseph F., Jr. ;

Stadecker, Miguel J. ;

Gause, William C. .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (12) :975-987

[4] Prevention of psoriasis-like lesions development in fsn/fsn mice by helminth glycans [J].

Atochina, O ;

Harn, D .

EXPERIMENTAL DERMATOLOGY, 2006, 15 (06) :461-468

[5] Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: Implications for parasite persistence [J].

Babu, S ;

Blauvelt, CP ;

Kumaraswami, V ;

Nutman, TB .

JOURNAL OF IMMUNOLOGY, 2006, 176 (05) :3248-3256

[6] E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury [J].

Bachmaier, Kurt ;

Toya, Sophie ;

Gao, Xiaopei ;

Triantafillou, Thomas ;

Garrean, Sean ;

Park, Gye Young ;

Frey, Randall S. ;

Vogel, Stephen ;

Minshall, Richard ;

Christman, John W. ;

Tiruppathi, Chinnaswamy ;

Malik, Asrar B. .

NATURE MEDICINE, 2007, 13 (08) :920-926

[7]

Branemark P I, 1977, Scand J Plast Reconstr Surg Suppl, V16, P1

[8] The Schistosoma mansoni Protein Sm16/SmSLP/SmSPO-1 Assembles into a Nine-Subunit Oligomer with Potential To Inhibit Toll-Like Receptor Signaling [J].

Brannstrom, Kristoffer ;

Sellin, Mikael E. ;

Holmfeldt, Per ;

Brattsand, Maria ;

Gullberg, Martin .

INFECTION AND IMMUNITY, 2009, 77 (03) :1144-1154

[9] Galectin-3 modulates immune and inflammatory responses during helminthic infection: Impact of galectin-3 deficiency on the functions of dendritic cells [J].

Breuilh, Laetitia ;

Vanhoutte, Francois ;

Fontaine, Josette ;

van Stijn, Caroline M. W. ;

Tillie-Leblond, Isabelle ;

Capron, Monique ;

Faveeuw, Christelle ;

Jouault, Thierry ;

van Die, Irma ;

Gosset, Philippe ;

Trottein, Francois .

INFECTION AND IMMUNITY, 2007, 75 (11) :5148-5157

[10] Review series on helminths, immune modulation and the hygiene hypothesis: Mechanisms underlying helminth modulation of dendritic cell function [J].

Carvalho, Lucas ;

Sun, Jie ;

Kane, Colleen ;

Marshall, Fraser ;

Krawczyk, Connie ;

Pearce, Edward J. .

IMMUNOLOGY, 2009, 126 (01) :28-34

← 1 2 3 4 5 6 7 8 →