Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity

被引：77

作者：

Flannigan, Kyle L. ^{[1
,2
]}

Denning, Timothy L. ^{[3
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB, Canada

[2] Univ Calgary, Snyder Inst Chron Dis, Calgary, AB, Canada

[3] Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA

来源：

IMMUNOLOGY | 2018年 / 154卷 / 04期

基金：

美国国家卫生研究院;

关键词：

autoimmunity; immune homeostasis; microbiota; mucosal immunology; segmented filamentous bacteria; Th17; cells; T-CELL RESPONSES; INNATE LYMPHOID-CELLS; GUT MICROBIOTA; HELPER-CELLS; TH17; CELLS; INTESTINAL INFLAMMATION; COMMENSAL BACTERIA; T(H)17 CELLS; SMALL-BOWEL; DIFFERENTIATION;

D O I：

10.1111/imm.12950

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Segmented filamentous bacteria (SFB) are Gram-positive, spore-forming, bacteria that primarily colonize the ileum of the small intestine. Upon direct adherence to intestinal epithelial cells, SFB actively stimulate innate and adaptive immune cell activation. The cardinal features of SFB-induced gut immunity - T helper type 17 (Th17) cell differentiation, IgA production and barrier protection - lead to the containment of SFB and further afford protection against invading pathogens. Th17 cells and interleukin-17A, however, can also reach peripheral sites and exacerbate autoimmunity. In this review, we highlight salient characteristics of SFB-host interactions and detail the cellular and molecular immune mechanisms involved in coordinating these responses.

引用

页码：537 / 546

页数：10

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