Association of the SDF1-3'A polymorphism with susceptibility to myocardial infarction in Chinese Han population

被引:16
|
作者
Luan, Bo [1 ,2 ]
Han, Yaling [1 ]
Zhang, Xiaolin [1 ]
Kang, Jian [1 ]
Yan, Chenghui [1 ]
机构
[1] Northern Hosp, Dept Cardiol, Cardiovasc Res Inst, Shenyang 110016, Peoples R China
[2] Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China
关键词
SDF-1; Mycardial infarction; Genetics; Polymorphism; CORONARY-ARTERY-DISEASE; FACTOR-I; ATHEROSCLEROSIS; CHEMOKINE; SDF-1; INFLAMMATION; CHEMOATTRACTANT; NEUTROPHILS; MECHANISMS; EXPRESSION;
D O I
10.1007/s11033-009-9845-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
SDF-1 has been demonstrated to be involved in the pathophysiology of atherosclerosis. This study was aimed to investigate whether the SDF1-3'A polymorphism (rs1801157) is associated to myocardial infarction (MI) in a sample of Chinese Han population. A total of 560 patients with MI and 532 controls were enrolled in the study. The SDF1-3'A polymorphism was determined by polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) analysis. A significant difference in genotype distribution and allele frequency was observed between patients and controls (P = 0.003 and P = 0.001, respectively). The A allele carriers had a significantly reduced MI risk compared with the GG homozygotes (OR, 0.69; 95% CI, 0.52-0.92; adjusted P = 0.007) in a logistic regression model after controlling conventional risk factors. The present study showed a significant association between the SDF1-3'A polymorphism and MI in Chinese Han population.
引用
收藏
页码:399 / 403
页数:5
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