Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors: 2020 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO/DGHO)

被引：55

作者：

Classen, Annika Y. ^{[1
,2
,3
]}

Henze, Larissa ^{[4
]}

Von Lilienfeld-Toal, Marie ^{[5
]}

Maschmeyer, Georg ^{[6
]}

Sandherr, Michael ^{[7
]}

Graeff, Luisa Duran ^{[1
,2
,3
]}

Alakel, Nael ^{[8
]}

Christopeit, Maximilian ^{[9
]}

Krause, Stefan W. ^{[10
]}

Mayer, Karin ^{[11
]}

Neumann, Silke ^{[12
]}

Cornely, Oliver A. ^{[1
,2
,3
,13
,14
]}

Penack, Olaf ^{[15
]}

Weissinger, Florian ^{[16
]}

Wolf, Hans-Heinrich ^{[17
]}

Vehreschild, Joerg Janne ^{[1
,2
,3
,18
]}

机构：

[1] Univ Cologne, Fac Med, Herderstr 52-54, D-50931 Cologne, Germany

[2] Univ Cologne, Univ Hosp Cologne, Dept Internal Med 1, Herderstr 52-54, D-50931 Cologne, Germany

[3] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, Cologne, Germany

[4] Rostock Univ, Med Ctr, Dept Med, Clin Hematol Oncol Palliat Med 3, Rostock, Germany

[5] Univ Hosp Jena, Clin Internal Med 2, Dept Hematol & Oncol, Jena, Germany

[6] Klinikum Ernst von Bergmann, Hematol Oncol & Palliat Care, Potsdam, Germany

[7] Med Care Ctr Penzberg, Specialist Clin Haematol & Oncol, Penzberg, Germany

[8] Univ Hosp Dresden, Dept Internal Med Hematol & Oncol 1, Dresden, Germany

[9] Univ Hosp Tubingen, Dept Internal Med Hematol Oncol Clin Immunol & Rh, Tubingen, Germany

[10] Univ Hosp Erlangen, Dept Med Hematol & Oncol 5, Erlangen, Germany

[11] Univ Hosp Bonn UKB, Med Clin Oncol Hematol Immunooncol & Rheumatol 3, Bonn, Germany

[12] Interdisciplinary Ctr Oncol, Wolfsburg, Germany

[13] Univ Cologne, Univ Hosp Cologne, Chair Translat Res, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany

[14] Univ Cologne, Univ Hosp Cologne, Clin Trials Ctr Cologne ZKS Koln, Cologne, Germany

[15] Charite Univ Med Berlin, Med Dept Hematol Oncol & Tumor Immunol, Campus Virchow Klinikum, Berlin, Germany

[16] Evangel Klinikum Bethel v Bodelschwinghsche Stift, Dept Internal Med Hematol Oncol & Palliat Care, Bielefeld, Germany

[17] Univ Hosp Halle, Dept Internal Med 4, Halle, Germany

[18] Goethe Univ Frankfurt, Dept Internal Med, Hematol Oncol, Frankfurt, Germany

来源：

ANNALS OF HEMATOLOGY | 2021年 / 100卷 / 06期

关键词：

Neutropenia; Prophylaxis; Bacterial infections; Resistance; Pneumocystis; STEM-CELL TRANSPLANTATION; BLOOD-STREAM INFECTIONS; LACTAMASE-PRODUCING ENTEROBACTERIACEAE; CLOSTRIDIUM-DIFFICILE INFECTION; FEBRILE NEUTROPENIC PATIENTS; ACUTE-LEUKEMIA PATIENTS; ACUTE MYELOID-LEUKEMIA; HIGH-RISK PATIENTS; CARINII-PNEUMONIA; TRIMETHOPRIM-SULFAMETHOXAZOLE;

D O I：

10.1007/s00277-021-04452-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematologic and oncologic patients with chemo- or immunotherapy-related immunosuppression are at substantial risk for bacterial infections and Pneumocystis jirovecii pneumonia (PcP). As bacterial resistances are increasing worldwide and new research reshapes our understanding of the interactions between the human host and bacterial commensals, administration of antibacterial prophylaxis has become a matter of discussion. This guideline constitutes an update of the 2013 published guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO). It gives an overview about current strategies for antibacterial prophylaxis in cancer patients while taking into account the impact of antibacterial prophylaxis on the human microbiome and resistance development. Current literature published from January 2012 to August 2020 was searched and evidence-based recommendations were developed by an expert panel. All recommendations were discussed and approved in a consensus conference of the AGIHO prior to publication. As a result, we present a comprehensive update and extension of our guideline for antibacterial and PcP prophylaxis in cancer patients.

引用

页码：1603 / 1620

页数：18

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