Vitamin D insufficiency in the first 6 months of infancy and challenge-proven IgE-mediated food allergy at 1 year of age: a case-cohort study

被引：51

作者：

Molloy, J. ^{[1
,2
,3
,4
]}

Koplin, J. J. ^{[3
,4
,5
]}

Allen, K. J. ^{[3
,4
,6
,7
]}

Tang, M. L. K. ^{[3
,4
,6
,7
]}

Collier, F. ^{[1
,2
,3
]}

Carlin, J. B. ^{[3
,5
,6
]}

Saffery, R. ^{[3
]}

Burgner, D. ^{[3
,6
,8
]}

Ranganathan, S. ^{[3
,6
,9
]}

Dwyer, T. ^{[10
]}

Ward, A. C. ^{[1
]}

Moreno-Betancur, M. ^{[3
,11
]}

Clarke, M. ^{[12
]}

Ponsonby, A. L. ^{[3
,4
]}

Vuillermin, P. ^{[1
,2
,3
,4
]}

机构：

[1] Deakin Univ, Sch Med, Waurn Ponds, Vic, Australia

[2] Barwon Hlth, Child Hlth Res Unit, Kitchener House,Ryrie St, Geelong, Vic 3220, Australia

[3] Murdoch Childrens Res Inst, Parkville, Vic, Australia

[4] Ctr Food & Allergy Res, Parkville, Vic, Australia

[5] Univ Melbourne, Ctr Epidemiol & Biostat, Carlton, Vic, Australia

[6] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[7] Royal Childrens Hosp, Dept Allergy & Immunol, Parkville, Vic, Australia

[8] Monash Univ, Dept Paediat, Clayton, Vic, Australia

[9] Royal Childrens Hosp, Dept Resp Med, Parkville, Vic, Australia

[10] Univ Oxford, George Inst Global Hlth, Oxford, England

[11] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia

[12] Univ Western Australia, Ctr Microscopy Characterisat & Anal, Biol & Mol Mass Spectrometry Facil, Perth, WA 6009, Australia

来源：

ALLERGY | 2017年 / 72卷 / 08期

基金：

英国医学研究理事会;

关键词：

cohort; eczema; food allergy; paediatrics; vitamin D; PARTY DIAGNOSTIC-CRITERIA; ATOPIC-DERMATITIS; 25-HYDROXYVITAMIN D; EARLY-CHILDHOOD; SUN EXPOSURE; D DEFICIENCY; CHILDREN; BIRTH; PREVALENCE; ANAPHYLAXIS;

D O I：

10.1111/all.13122

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Ecological evidence suggests vitamin D insufficiency (VDI) due to lower ambient ultraviolet radiation (UVR) exposure may be a risk factor for IgE-mediated food allergy. However, there are no studies relating directly measured VDI during early infancy to subsequent challenge-proven food allergy. Objective: To prospectively investigate the association between VDI during infancy and challenge-proven food allergy at 1 year. Methods: In a birth cohort (n = 1074), we used a case-cohort design to compare 25-hydroxyvitamin D-3 (25(OH) D3) levels among infants with food allergy vs a random subcohort (n = 274). The primary exposures were VDI (25(OH) D3 <50 nM) at birth and 6 months of age. Ambient UVR and time in the sun were combined to estimate UVR exposure dose. IgE-mediated food allergy status at 1 year was determined by formal challenge. Binomial regression was used to examine associations between VDI, UVR exposure dose and food allergy and investigate potential confounding. Results: Within the random subcohort, VDI was present in 45% (105/233) of newborns and 24% (55/227) of infants at 6 months. Food allergy prevalence at 1 year was 7.7% (61/786), and 6.5% (53/808) were egg-allergic. There was no evidence of an association between VDI at either birth (aRR 1.25, 95% CI 0.70-2.22) or 6 months (aRR 0.93, 95% CI 0.41-2.14) and food allergy at 1 year. Conclusions: There was no evidence that VDI during the first 6 months of infancy is a risk factor for food allergy at 1 year of age. These findings primarily relate to egg allergy, and larger studies are required.

引用

页码：1222 / 1231

页数：10

共 58 条

[1] Vitamin D insufficiency is associated with challenge-proven food allergy in infants [J].