Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions

被引:72
作者
Chitu, Vioieta [1 ]
Stanley, E. Richard [1 ]
机构
[1] Albert Einstein Coll Med, Dept Dev Biol & Mol Biol, Bronx, NY 10461 USA
关键词
D O I
10.1016/j.tcb.2007.01.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cellular adhesion, motility, endocytosis, exocytosis and cytokinesis involve the coordinated reorganization of the cytoskeleton and of the plasma membrane. The 'Pombe Cdc15 homology' (PCH) family of adaptor proteins has recently been shown to coordinate the membrane and cytoskeletal dynamics involved in these processes by curving membranes, recruiting dynamin and controlling the architecture of the actin cytoskeleton. Mutations in PCH family members or proteins that interact with them are associated with autoinflammatory, neurological or neoplastic diseases. Here, we review the nature, actions and disease associations of the vertebrate PCH family members, highlighting their fundamental roles in the regulation of processes involving membrane-cytoskeletal interactions.
引用
收藏
页码:145 / 156
页数:12
相关论文
共 104 条
[91]   Splicing variant of Cdc42 interacting protein-4 disrupts β-catenin-mediated cell-cell adhesion:: Expression and function in renal cell carcinoma [J].
Tsuji, E ;
Tsuji, Y ;
Fujiwara, T ;
Ogata, S ;
Tsukamoto, K ;
Saku, K .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 339 (04) :1083-1088
[92]   Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis [J].
Tsujita, K ;
Suetsugu, S ;
Sasaki, N ;
Furutani, M ;
Oikawa, T ;
Takenawa, T .
JOURNAL OF CELL BIOLOGY, 2006, 172 (02) :269-279
[93]   Fer and Fps/Fes participate in a Lyn-dependent pathway from FcεRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation [J].
Udell, Christian M. ;
Samayawardhena, Lionel A. ;
Kawakami, Yuko ;
Kawakami, Toshiaki ;
Craig, Andrew W. B. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (30) :20949-20957
[94]   Underfill of flip chip on organic substrate: viscosity, surface tension, and contact angle [J].
Wang, JL .
MICROELECTRONICS RELIABILITY, 2002, 42 (02) :293-299
[95]   The Ras/Rac guanine nucleotide exchange factor mammalian son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton [J].
Wasiak, S ;
Quinn, CC ;
Ritter, B ;
de Heuvel, E ;
Baranes, D ;
Plomann, M ;
McPherson, PS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :26622-26628
[96]   Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder [J].
Wise, CA ;
Gillum, JD ;
Seidman, CE ;
Lindor, NM ;
Veile, R ;
Bashiardes, S ;
Lovett, M .
HUMAN MOLECULAR GENETICS, 2002, 11 (08) :961-969
[97]   Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway [J].
Wong, K ;
Ren, XR ;
Huang, YZ ;
Xie, Y ;
Liu, GF ;
Saito, H ;
Tang, H ;
Wen, L ;
Brady-Kalnay, SM ;
Mei, L ;
Wu, JY ;
Xiong, WC ;
Rao, Y .
CELL, 2001, 107 (02) :209-221
[98]   PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase [J].
Wu, Y ;
Dowbenko, D ;
Lasky, LK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (46) :30487-30496
[99]   Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein [J].
Wu, Y ;
Spencer, SD ;
Lasky, LA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) :5765-5770
[100]   Mutually exclusive interactions of EHD1 with GS32 and syndapin II [J].
Xu, Y ;
Shi, H ;
Wei, SH ;
Wong, SH ;
Hong, WJ .
MOLECULAR MEMBRANE BIOLOGY, 2004, 21 (04) :269-277