共 104 条
Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions
被引:72
作者:

Chitu, Vioieta
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机构:
Albert Einstein Coll Med, Dept Dev Biol & Mol Biol, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Dev Biol & Mol Biol, Bronx, NY 10461 USA

Stanley, E. Richard
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机构:
Albert Einstein Coll Med, Dept Dev Biol & Mol Biol, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Dev Biol & Mol Biol, Bronx, NY 10461 USA
机构:
[1] Albert Einstein Coll Med, Dept Dev Biol & Mol Biol, Bronx, NY 10461 USA
关键词:
D O I:
10.1016/j.tcb.2007.01.003
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Cellular adhesion, motility, endocytosis, exocytosis and cytokinesis involve the coordinated reorganization of the cytoskeleton and of the plasma membrane. The 'Pombe Cdc15 homology' (PCH) family of adaptor proteins has recently been shown to coordinate the membrane and cytoskeletal dynamics involved in these processes by curving membranes, recruiting dynamin and controlling the architecture of the actin cytoskeleton. Mutations in PCH family members or proteins that interact with them are associated with autoinflammatory, neurological or neoplastic diseases. Here, we review the nature, actions and disease associations of the vertebrate PCH family members, highlighting their fundamental roles in the regulation of processes involving membrane-cytoskeletal interactions.
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页码:145 / 156
页数:12
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