γ-Butyrolactones from Aspergillus Species: Structures, Biosynthesis, and Biological Activities

被引:36
作者
Ibrahim, Sabrin R. M. [1 ,2 ]
Mohamed, Gamal A. [3 ,4 ]
Khedr, Amgad I. M. [5 ]
机构
[1] Taibah Univ, Coll Pharm, Dept Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawarah 30078, Saudi Arabia
[2] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71526, Egypt
[3] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah 21589, Saudi Arabia
[4] Al Azhar Univ, Assiut Branch, Fac Pharm, Dept Pharmacognosy, Assiut 71524, Egypt
[5] Port Said Univ, Fac Pharm, Dept Pharmacognosy, Port Said 42526, Egypt
关键词
Aspergillus; gamma-Butyrolactones; Biosynthesis; Biological activities; METABOLIC PRODUCTS; SECONDARY METABOLITES; FERMENTATION PRODUCTS; SELECTIVE INHIBITOR; KINASE INHIBITOR; I DERIVATIVES; FUNGUS; TERREUS; STRAIN; BUTENOLIDE;
D O I
10.1177/1934578X1701200526
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Recently, numerous metabolites possessing uncommon structures and potent bioactivity have been isolated from strains of fungi collected from diverse environments. The genus Aspergillus is known as a rich source of gamma-butyrolactones. These are a group of fungal secondary metabolites, consisting of a five-membered lactone bearing two aromatic rings, which shows a great variety of biological activities. This review summarizes the research on the biosynthesis, source, and biological activities of the naturally occurring gamma-butyrolactones that have been isolated from Aspergillus species published over the last decades. More than 75 compounds are described and 65 references are cited.
引用
收藏
页码:791 / 800
页数:10
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