Simultaneous estimation of Rosuvastatin calcium and Ezetimibe in tablet dosage form by reverse phase high performance liquid chromatography

被引：0
|
作者：
Sharma, Smita [2 ]
Sharma, M. C. [1 ]
Kohli, D. V. [3 ]
Chaturvedi, S. C. [4 ]
机构：
[1] Devi Ahilya Vishwavidyalaya, Sch Pharm, Indore 452001, Madhya Pradesh, India
[2] Yadhunath Mahavidyalya, Dept Chem, Bhind 477001, MP, India
[3] Dr HSG Univ, Dept Pharmaceut Sci, Sagar 470003, MP, India
[4] Shri Arvindo Inst Pharm, Indore 453111, Madhya Pradesh, India
来源：
OPTOELECTRONICS AND ADVANCED MATERIALS-RAPID COMMUNICATIONS | 2010年 / 4卷 / 02期
关键词：
Reverse phase -HPLC; Rosuvastatin calcium; Ezetimibe; HUMAN PLASMA;
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
This paper described validated high performance liquid chromatographic (HPLC) method for estimation of Rosuvastatin Calcium (ROS) and Ezetimibe (EZE) in tablet dosage form. HPLC separation was achieved on Licrosphere C,8 column (250 x 4.6mm) using Methanol: Acetonitrile: Phosphate buffer, pH 3.5(60:20:20 v/v) at flow rate of 1.0ml/min at 25 degrees C temperature. Quantitation was achieved by UV detection at 279 nm over the concentration range 5-10 mg/ml for both the drugs with mean recoveries of 99.01% +/- 0.12 and 100.64% +/- 0.20 for ROS and EZE respectively. This method is simple, precise and sensitive and it is applicable for the simultaneous estimation of ROS and EZE in tablet dosage form.
引用
收藏
页码：238 / 241
页数：4
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