Thrombopoietin in Plasmodium falciparum malaria

被引：30
作者：
Kreil, A
Wenisch, C
Brittenham, G
Looareesuwan, S
Peck-Radosavljevic, M
机构：
[1] Univ Hosp Vienna, Dept Internal Med 4, Div Gastroenterol, A-1090 Vienna, Austria
[2] Graz Univ, Dept Internal Med, Div Infect Dis, A-8010 Graz, Austria
[3] Mahidol Univ, Fac Trop Med, Hosp Trop Dis, Bangkok 10700, Thailand
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 109卷 / 03期
关键词：
malaria; Plasmodium falciparum; thrombopoietin (TPO); peripheral platelet count (PPC); disseminated intravascular coagulation (DIC);
D O I：
10.1046/j.1365-2141.2000.02096.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients with severe malaria (n = 35) than in patients with uncomplicated malaria (n = 44; P = 0.024), normalizing within 14-21 d of therapy. The rapid normalization of TPO levels and increase in low peripheral platelet counts after treatment indicate that the biosynthesis of TPO and its regulation in malaria patients are normal.
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收藏
页码：534 / 536
页数：3
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