Thrombopoietin in Plasmodium falciparum malaria

被引：30

作者：

Kreil, A

Wenisch, C

Brittenham, G

Looareesuwan, S

Peck-Radosavljevic, M

机构：

[1] Univ Hosp Vienna, Dept Internal Med 4, Div Gastroenterol, A-1090 Vienna, Austria

[2] Graz Univ, Dept Internal Med, Div Infect Dis, A-8010 Graz, Austria

[3] Mahidol Univ, Fac Trop Med, Hosp Trop Dis, Bangkok 10700, Thailand

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 109卷 / 03期

关键词：

malaria; Plasmodium falciparum; thrombopoietin (TPO); peripheral platelet count (PPC); disseminated intravascular coagulation (DIC);

D O I：

10.1046/j.1365-2141.2000.02096.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients with severe malaria (n = 35) than in patients with uncomplicated malaria (n = 44; P = 0.024), normalizing within 14-21 d of therapy. The rapid normalization of TPO levels and increase in low peripheral platelet counts after treatment indicate that the biosynthesis of TPO and its regulation in malaria patients are normal.

引用

页码：534 / 536

页数：3

共 12 条

[1] Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction [J].