Coordination-driven self-assembly of ruthenium(II) architectures: synthesis, characterization and cytotoxicity studies

被引：17

作者：

Adeyemo, Aderonke Ajibola ^{[1
]}

Shettar, Abhijith ^{[2
,3
]}

Bhat, Imtiyaz Ahmad ^{[1
]}

Kondaiah, Paturu ^{[2
]}

Mukherjee, Partha Sarathi ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Mol Reprod Dev & Genet, Bangalore 560012, Karnataka, India

[3] Ramaiah Inst Technol, Dept Biotechnol Engn, Bangalore 560064, Karnataka, India

来源：

DALTON TRANSACTIONS | 2018年 / 47卷 / 25期

关键词：

ANTICANCER ACTIVITY; SUPRAMOLECULAR CATALYSIS; COMBINATORIAL CHEMISTRY; ANTITUMOR DRUGS; METAL-COMPLEXES; DNA-BINDING; DISCRETE; LIGANDS; CISPLATIN; APOPTOSIS;

D O I：

10.1039/c8dt00962g

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Coordination-driven self-assembly of organometallic eta(6)-arene ruthenium(ii) supramolecular architectures (MA(1)-MA(4)) was carried out by employing dinuclear ruthenium acceptors [Ru-2(mu-eta(4)-C2O4)(CH3OH)(2)(eta(6)-p-cymene)(2)](CF3SO3)(2) (Ru-a), [Ru-2(mu-eta(4)-C6H2O4)(CH3OH)(2)(eta(6)-p-cymene)(2)](CF3SO3)(2) (Ru-b), [Ru-2(dhnq)(H2O)(2)(eta(6)-p-cymene)(2)](CF3SO3)(2) (Ru-c) and [Ru-2(dhtq)(H2O)(2)((6)-p-cymene)(2)](CF3SO3)(2) (Ru-d) separately with a new tetratopic donor (TD) in methanol at room temperature [TD = N,N,N,N-tetra(pyridin-4-yl)-[1,1-biphenyl]-4,4-diamine]. All the coordination architectures were characterized by using spectroscopic techniques. The potency of these self-assembled architectures against human cervical cancer HeLa and human lung adenocarcinoma A549 cell lines is explored in vitro using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), annexin V-FITC/PI and 2,7-dichlorofluorescein-diacetate assays.

引用

页码：8466 / 8475

页数：10

共 92 条

[1] Template-free coordination-driven self-assembly of discrete hexanuclear prismatic cages employing half-sandwich octahedral Ru2II acceptors and triimidazole donors [J].

Adeyemo, Aderonke Ajibola ;

Shanmugaraju, Sankarasekaran ;

Samanta, Dipak ;

Mukherjee, Partha Sarathi .

INORGANICA CHIMICA ACTA, 2016, 440 :62-68

[2] Use of the Graebe-Ullmann reaction in the synthesis of 8-methyl-γ-carboline and isomeric aromatic aza-γ-carbolines [J].

Alekseev, R. S. ;

Kurkin, A. V. ;

Yurovskaya, M. A. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2012, 48 (08) :1235-1250

[3]

Arterburn JB, 2000, ANGEW CHEM INT EDIT, V39, P771, DOI 10.1002/(SICI)1521-3773(20000218)39:4<771::AID-ANIE771>3.3.CO

[4]

2-5

[5] Dinuclear Ruthenium( II) Complexes as Two- Photon, Time- Resolved Emission Microscopy Probes for Cellular DNA [J].

Baggaley, Elizabeth ;

Gill, Martin R. ;

Green, Nicola H. ;

Turton, David ;

Sazanovich, Igor V. ;

Botchway, Stanley W. ;

Smythe, Carl ;

Haycock, John W. ;

Weinstein, Julia A. ;

Thomas, Jim A. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (13) :3367-3371

[6] In- and Out-of-Cavity Interactions by Modulating the Size of Ruthenium Metallarectangles [J].

Barry, Nicolas P. E. ;

Furrer, Julien ;

Therrien, Bruno .

HELVETICA CHIMICA ACTA, 2010, 93 (07) :1313-1328

[7] Host-Guest Chemistry in the Hexanuclear (Arene)ruthenium Metalla-Prismatic Cage [Ru6(p-cymene)6(tpt)2(dhnq)3]6+ [J].

Barry, Nicolas P. E. ;

Therrien, Bruno .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2009, (31) :4695-4700

[8] Route to cluster helicates [J].

Bermejo, MR ;

González-Noya, AM ;

Pedrido, RM ;

Romero, MJ ;

Vázquez, M .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (27) :4182-4187

[9] Antimicrobial activity of ruthenium-based intercalators [J].

Bolhuis, Albert ;

Hand, Lorna ;

Marshall, Julia E. ;

Richards, Adair D. ;

Rodger, Alison ;

Aldrich-Wright, Janice .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 42 (04) :313-317

[10] DNA INTERSTRAND CROSS-LINKS OF TRANS-DIAMMINEDICHLOROPLATINUM(II) ARE PREFERENTIALLY FORMED BETWEEN GUANINE AND COMPLEMENTARY CYTOSINE RESIDUES [J].

BRABEC, V ;

LENG, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) :5345-5349

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