Plasma enhance drug sensitivity to bortezomib by inhibition of cyp1a1 in myeloma cells

被引：4

作者：

Xu, Dehui ^{[1
]}

Cui, Qingjie ^{[2
]}

Xu, Yujing ^{[1
]}

Chen, Zeyu ^{[1
]}

Xia, Wenjie ^{[1
]}

Yang, Yanjie ^{[3
]}

Liu, Dingxin ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Ctr Plasma Biomed, State Key Lab Elect Insulat & Power Equipment, Xian 710049, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Sch, Sch Life Sci & Technol, Xian 710049, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Sch, Dept Cardiovasc Med, 277 Yanta West Rd, Xian 710049, Shaanxi, Peoples R China

来源：

TRANSLATIONAL CANCER RESEARCH | 2019年 / 8卷 / 08期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Cold atmospheric plasma; cyp1a1; drug resistance; multiple myeloma (MM); notch; MULTIPLE-MYELOMA; RESISTANCE; ACTIVATION; DEATH;

D O I：

10.21037/tcr.2019.10.43

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Drug resistance is one of the major problems encountered in clinical therapy of multiple myeloma treatment. Combination treatment with several drugs may increase the sensitivity and overcome drug resistance. Methods: Here, we combined chemotherapy with a newly developed technology, cold atmospheric plasma, to enhance drug sensitivity. Results: We found that plasma treatment had a synergistic anti-cancer effect with a first line drug (bortezomib). Based on our previous study, we further found that plasma treatment could inhibit Notch pathway and down-regulate cyp1a1 expression and enzyme activity, which contributing to the enhanced drug sensitivity to bortezomib after combination of bortezomib with gas plasma. Conclusions: Our results showed a new strategy to overcome drug resistance by combination of traditional chemotherapy with cold atmospheric plasma.

引用

页码：2841 / +

页数：10

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