Plasma enhance drug sensitivity to bortezomib by inhibition of cyp1a1 in myeloma cells

被引：4
作者：
Xu, Dehui [1 ]
Cui, Qingjie [2 ]
Xu, Yujing [1 ]
Chen, Zeyu [1 ]
Xia, Wenjie [1 ]
Yang, Yanjie [3 ]
Liu, Dingxin [1 ]
机构：
[1] Xi An Jiao Tong Univ, Ctr Plasma Biomed, State Key Lab Elect Insulat & Power Equipment, Xian 710049, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Sch, Sch Life Sci & Technol, Xian 710049, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Sch, Dept Cardiovasc Med, 277 Yanta West Rd, Xian 710049, Shaanxi, Peoples R China
来源：
TRANSLATIONAL CANCER RESEARCH | 2019年 / 8卷 / 08期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Cold atmospheric plasma; cyp1a1; drug resistance; multiple myeloma (MM); notch; MULTIPLE-MYELOMA; RESISTANCE; ACTIVATION; DEATH;
D O I：
10.21037/tcr.2019.10.43
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Drug resistance is one of the major problems encountered in clinical therapy of multiple myeloma treatment. Combination treatment with several drugs may increase the sensitivity and overcome drug resistance. Methods: Here, we combined chemotherapy with a newly developed technology, cold atmospheric plasma, to enhance drug sensitivity. Results: We found that plasma treatment had a synergistic anti-cancer effect with a first line drug (bortezomib). Based on our previous study, we further found that plasma treatment could inhibit Notch pathway and down-regulate cyp1a1 expression and enzyme activity, which contributing to the enhanced drug sensitivity to bortezomib after combination of bortezomib with gas plasma. Conclusions: Our results showed a new strategy to overcome drug resistance by combination of traditional chemotherapy with cold atmospheric plasma.
引用
收藏
页码：2841 / +
页数：10
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