The Emerging Roles and Clinical Potential of circSMARCA5 in Cancer

被引:8
作者
Xue, Changning [1 ,2 ,3 ]
Wei, Jianxia [1 ,2 ,3 ]
Li, Mengna [1 ,2 ,3 ]
Chen, Shipeng [1 ,2 ,3 ]
Zheng, Lemei [1 ,2 ,3 ]
Zhan, Yuting [4 ]
Duan, Yumei [1 ,2 ,3 ]
Deng, Hongyu [1 ,2 ]
Xiong, Wei [1 ,2 ,3 ]
Li, Guiyuan [1 ,2 ,3 ]
Li, Hui [4 ]
Zhou, Ming [1 ,2 ,3 ]
机构
[1] Cent South Univ, Hunan Canc Hosp, Affiliated Canc Hosp,Xiangya Sch Med, NHC Key Lab Carcinogenesis,Hunan Key Lab Oncotarg, Changsha 410013, Peoples R China
[2] Cent South Univ, Sch Basic Med Sci, Canc Res Inst, Changsha 410078, Peoples R China
[3] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha 410078, Peoples R China
[4] Cent South Univ, Xiangya Hosp 2, Changsha 410011, Peoples R China
基金
中国国家自然科学基金;
关键词
cancer; circSMARCA5; dual roles; ceRNA; tumor progression; CIRCULAR RNA SMARCA5; PROMOTES CELL-PROLIFERATION; LUNG-CANCER; MIGRATION; INVASION; PROGRESSION; MECHANISMS; EXPRESSION; LANDSCAPE; PROTEINS;
D O I
10.3390/cells11193074
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Circular RNAs (circRNAs) are a type of endogenous non-coding RNA and a critical epigenetic regulation way that have a closed-loop structure and are highly stable, conserved, and tissue-specific, and they play an important role in the development of many diseases, including tumors, neurological diseases, and cardiovascular diseases. CircSMARCA5 is a circRNA formed by its parental gene SMARCA5 via back splicing which is dysregulated in expression in a variety of tumors and is involved in tumor development with dual functions as an oncogene or tumor suppressor. It not only serves as a competing endogenous RNA (ceRNA) by binding to various miRNAs, but it also interacts with RNA binding protein (RBP), regulating downstream gene expression; it also aids in DNA damage repair by regulating the transcription and expression of its parental gene. This review systematically summarized the expression and characteristics, dual biological functions, and molecular regulatory mechanisms of circSMARCA5 involved in carcinogenesis and tumor progression as well as the potential applications in early diagnosis and gene targeting therapy in tumors.
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页数:15
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