Role of Calcium in Platelet Activation: Novel Insights and Pharmacological Implications

被引：32
作者：
Davlouros, Periklis [1 ]
Xanthopoulou, Ioanna [1 ]
Mparampoutis, Nikolaos [1 ]
Giannopoulos, Georgios [2 ]
Deftereos, Spyridon [2 ]
Alexopoulos, Dimitrios [1 ]
机构：
[1] Patras Univ Hosp, Dept Cardiol, Patras 26504, Greece
[2] Yale Univ, Sch Med, Sect Cardiovasc Med, New Haven, CT USA
来源：
MEDICINAL CHEMISTRY | 2016年 / 12卷 / 02期
关键词：
Platelets; activation; calcium; kinetics; PERCUTANEOUS CORONARY INTERVENTION; PERMEABILITY TRANSITION PORE; PROCOAGULANT ACTIVITY; ACTIN CYTOSKELETON; BLEEDING EVENTS; CALDAG-GEFI; CLOPIDOGREL; RECEPTORS; CHANNEL; ENTRY;
D O I：
10.2174/157340641202160208195923
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Platelets are involved in haemostasis and vessel integrity under physiologic conditions, and in thrombosis under disease states. Platelet activation upon stimulation with various agonists in vitro and in vivo, is strongly dependent on an increase of intracellular Ca2+ concentration. The latter results from Ca2+ release by the dense tubular system (DTS), and Ca2+ entry from the extracellular space. Recent advances in identification of the molecular mechanisms involved in these processes are described in this review, along with potential targets for pharmacologic interventions in disease states.
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收藏
页码：131 / 138
页数：8
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