Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study

被引:12
作者
Sauder, Katherine A. [1 ]
Koeppen, Hallie J. [2 ]
Shapiro, Allison L. B. [2 ]
Kalata, Kathryn E. [1 ]
Stamatoiu, Alexandra V. [2 ]
Ringham, Brandy M. [3 ]
Glueck, Deborah H. [3 ]
Norris, Jill M. [2 ]
Dabelea, Dana [1 ,2 ]
机构
[1] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA
[2] Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO 80045 USA
[3] Colorado Sch Publ Hlth, Dept Biostat & Informat, Aurora, CO 80045 USA
基金
美国国家卫生研究院;
关键词
vitamin D; pregnancy; birth; body composition; adiposity; FOR-GESTATIONAL-AGE; EPISODICALLY CONSUMED FOODS; D DEFICIENCY; D SUPPLEMENTATION; CHILDHOOD ADIPOSITY; MATERNAL OBESITY; D INSUFFICIENCY; BIRTH OUTCOMES; WEIGHT-GAIN; PREGNANCY;
D O I
10.3390/nu9070790
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Vitamin D deficiency in pregnancy may be associated with increased offspring adiposity, but evidence from human studies is inconclusive. We examined associations between prenatal vitamin D intake, 25-hydroxyvitamin D (25(OH) D) in cord blood, and offspring size and body composition at birth and 5 months. Participants included 605 mother-offspring dyads from the Healthy Start study, an ongoing, pre-birth prospective cohort study in Denver, Colorado, USA. Prenatal vitamin D intake was assessed with diet recalls and questionnaires, and offspring body composition was measured via air displacement plethysmography at birth and 5 months. General linear univariate models were used for analysis, adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index (BMI), offspring sex, and gestational age at birth. Non-Hispanic white race, lower pre-pregnancy BMI, higher prenatal vitamin D intake, and summer births were associated with higher cord blood 25(OH) D. Higher 25(OH) D was associated with lower birthweight (beta = -6.22, p = 0.02), but as maternal BMI increased, this association became increasingly positive in direction and magnitude (beta = 1.05, p = 0.04). Higher 25(OH) D was also associated with lower neonatal adiposity (beta = -0.02, p < 0.05) but not after adjustment for maternal BMI (beta = -0.01, p = 0.25). Cord blood 25(OH) D was not associated with offspring size or body composition at 5 months. Our data confirm the hypothesis that vitamin D exposure in early life is associated with neonatal body size and composition. Future research is needed to understand the implications of these associations as infants grow.
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页数:14
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共 61 条
[1]   Body fat content and 25-hydroxyvitamin D levels in healthy women [J].
Arunabh, S ;
Pollack, S ;
Yeh, J ;
Aloia, JF .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :157-161
[2]   Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort [J].
Barebring, Linnea ;
Schoenmakers, Inez ;
Glantz, Anna ;
Hulthen, Lena ;
Jagner, Ase ;
Ellis, Joy ;
Barebring, Mattias ;
Bullarbo, Maria ;
Augustin, Hanna .
NUTRIENTS, 2016, 8 (10)
[3]   Nonclassic Actions of Vitamin D [J].
Bikle, Daniel .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (01) :26-34
[4]   Prepregnancy obesity predicts poor vitamin D status in mothers and their neonates [J].
Bodnar, Lisa M. ;
Catov, Janet M. ;
Roberts, James M. ;
Simhan, Hyagriv N. .
JOURNAL OF NUTRITION, 2007, 137 (11) :2437-2442
[5]   Early-Pregnancy Vitamin D Deficiency and Risk of Preterm Birth Subtypes [J].
Bodnar, Lisa M. ;
Platt, Robert W. ;
Simhan, Hyagriv N. .
OBSTETRICS AND GYNECOLOGY, 2015, 125 (02) :439-447
[6]   The impact of gestational diabetes and maternal obesity on the mother and her offspring [J].
Catalano, P. M. .
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 2010, 1 (04) :208-215
[7]  
Centers for Disease Control and Prevention, VDSCP LIST CERTIFIED
[8]   Maternal Vitamin D Deficiency During Pregnancy Elevates the Risks of Small for Gestational Age and Low Birth Weight Infants in Chinese Population [J].
Chen, Yuan-Hua ;
Fu, Lin ;
Hao, Jia-Hu ;
Yu, Zhen ;
Zhu, Peng ;
Wang, Hua ;
Xu, Yuan-Yuan ;
Zhang, Cheng ;
Tao, Fang-Biao ;
Xu, De-Xiang .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (05) :1912-1919
[9]   Maternal Micronutrient Deficiency, Fetal Development, and the Risk of Chronic Disease [J].
Christian, Parul ;
Stewart, Christine P. .
JOURNAL OF NUTRITION, 2010, 140 (03) :437-445
[10]   Evaluation of 25-hydroxy vitamin D assay on the immunodiagnostic systems iSYS analyser [J].
Cluse, Zee N. ;
Fudge, Andrew N. ;
Whiting, Malcolm J. ;
McWhinney, Brett ;
Parkinson, Ian ;
O'Loughlin, Peter D. .
ANNALS OF CLINICAL BIOCHEMISTRY, 2012, 49 :159-165