Hereditary Thyroid Cancer Syndromes and Genetic Testing

被引:18
作者
Rowland, Kathryn J. [1 ]
Moley, Jeffrey F. [1 ]
机构
[1] Washington Univ, Sch Med, Barnes Jewish Hosp, Div Endocrine & Oncol Surg,Dept Surg, St Louis, MO 63110 USA
关键词
medullary thyroid cancer; hereditary thyroid cancer; nonmedullary thyroid cancer; ret proto oncogene; multiple endocrine neoplasia; FAMILIAL ADENOMATOUS POLYPOSIS; FOLLICULAR CELL ORIGIN; RISK-REDUCING SURGERY; CLINICAL-CHARACTERISTICS; GERMLINE PTEN; CARCINOEMBRYONIC ANTIGEN; PROGNOSTIC-FACTORS; RET PROTOONCOGENE; MALIGNANT PROGRESSION; MOLECULAR DIAGNOSIS;
D O I
10.1002/jso.23769
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This review focuses on both hereditary medullary thyroid cancer (MTC) and hereditary nonmedullary thyroid cancer (NMTC) and discusses the genetics, clinical diagnosis and evaluation, and surgical approach to treatment of these malignancies. Areas of innovation as well as areas of debate are highlighted and management recommendations are made. J. Surg. Oncol. 2015 111:51-60. (c) 2014 Wiley Periodicals, Inc.
引用
收藏
页码:51 / 60
页数:10
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