Impact of N6-methyladenosine (m6A) modification on immunity

被引：27

作者：

Elsabbagh, Raghda A. ^{[1
]}

Rady, Mona ^{[2
,3
]}

Watzl, Carsten ^{[4
]}

Abou-Aisha, Khaled ^{[2
]}

Gad, Mohamed Z. ^{[1
]}

机构：

[1] German Univ Cairo, Fac Pharm & Biotechnol, Biochem Dept, Cairo, Egypt

[2] German Univ Cairo, Fac Pharm & Biotechnol, Microbiol Immunol & Biotechnol Dept, Cairo, Egypt

[3] German Int Univ, Fac Biotechnol, Cairo, Egypt

[4] TU Dortmund, Leibniz Res Ctr Working Environm & Human Factors, Dept Immunol, Dortmund, Germany

来源：

CELL COMMUNICATION AND SIGNALING | 2022年 / 20卷 / 01期

关键词：

N6-methyl-adenosine; Innate; Adaptive; Immunity; m(6)A writers; m(6)A erasers; m(6)A readers; METHYLTRANSFERASE METTL3 PROMOTES; MESSENGER-RNA TRANSLATION; N-6-METHYLADENOSINE MODIFICATION; GENE-EXPRESSION; FTO GENE; METHYLATION; DEMETHYLASE; PROTEINS; ALKBH5; CANCER;

D O I：

10.1186/s12964-022-00939-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

N6-methyl-adenosine (m(6)A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m(6)A relies on m(6)A writers, erasers and readers. m(6)A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m(6)A modification has been implicated in various human diseases. Thus, m(6)A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m(6)A in regulating immune cell functions and immune responses.

引用

页数：12

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