Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer

被引：18

作者：

Chiu, Helen H. L. ^{[1
]}

Yong, Theresa M. K. ^{[1
]}

Wang, Jun ^{[1
]}

Wang, Yuwei ^{[2
]}

Vessella, Robert L. ^{[3
]}

Ueda, Takeshi ^{[4
]}

Wang, Yu-Zhuo ^{[2
]}

Sadar, Marianne D. ^{[1
]}

机构：

[1] British Columbia Canc Agcy, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z 1L3, Canada

[2] British Columbia Canc Agcy, Dept Canc Endocrinol, Vancouver, BC V5Z 1L3, Canada

[3] Univ Washington, Med Ctr, Dept Urol, Seattle, WA 98195 USA

[4] Chiba Canc Ctr, Div Urol, Chuo Ku, Chiba 2608717, Japan

来源：

CANCER LETTERS | 2010年 / 292卷 / 02期

关键词：

Prostate cancer; Androgen deprivation; Nuclear factor-kappa B; Inhibitors of apoptosis; Neuronal apoptosis inhibitory protein; NF-KAPPA-B; SPINAL MUSCULAR-ATROPHY; TRANSCRIPTIONAL ACTIVATION; REGULATORY ELEMENTS; MAMMALIAN-CELLS; SURVIVIN; GENES; NAIP; IAP; ADENOCARCINOMA;

D O I：

10.1016/j.canlet.2009.11.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-kappa B that physically associated to previously uncharacterized kappa B-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased (p = 0 04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration (C) 2009 Elsevier Ireland Ltd. All rights reserved

引用

页码：176 / 185

页数：10

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