Case Report: Orbital Tumor Revealing Adult T-Cell Leukemia/Lymphoma Associated with Human T-Cell Lymphotropic Virus Type-1

被引：6

作者：

Fares, Selim ^{[1
]}

Hage, Rabih ^{[1
]}

Pegliasco, Jean ^{[2
]}

Chraibi, Samy ^{[2
]}

Merle, Harold ^{[1
]}

机构：

[1] Martinique Univ Hosp, Dept Ophthalmol, Fort De France, Martinique, France

[2] Martinique Univ Hosp, Dept Hematol, Fort De France, Martinique, France

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2018年 / 99卷 / 02期

关键词：

OCULAR MANIFESTATIONS; LEUKEMIA-LYMPHOMA; INFECTION; SURVIVAL; UVEITIS;

D O I：

10.4269/ajtmh.17-0137

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Adult T-cell Leukemia/Lymphoma (ATLL) is a sight-and life-threatening complication of human T-cell lymphotropic virus type 1 (HTLV-1) infection. Ophthalmic manifestations include uveitis, optic nerve oedema, retinal vasculitis, and lymphomatous infiltration. Orbital lesions are rare. We report the case of an orbital tumor revealing systemic ATLL in a 45-year-old Dominican patient who died despite treatment. Apart from late-grade cutaneous T-cell lymphoma, ATLL is the only T-lymphoma to develop in the orbit. Diagnosis is based on serologic evidence of HTLV-1 infection, cytology, and blood sample analysis. Biopsy is deemed necessary. Given the poor prognosis of ATLL and the worldwide presentation of HTLV-1, physicians should consider ATLL in the differential diagnosis of orbital malignant tumor and look for HTLV-1 infection in populations at risk.

引用

页码：435 / 438

页数：4

共 29 条

[21]

OHBA N, 1994, JPN J OPHTHALMOL, V38, P168

[22]

OHBA N, 1989, JPN J OPHTHALMOL, V33, P1

[23] Immunologic markers, uveitis, and keratoconjunctivitis sicca associated with human T-cell lymphotropic virus type 1 [J].

Pinheiro, Sonia Regina A. A. ;

Martins-Filho, Olindo A. ;

Ribas, Joao Gabriel R. ;

Catalan-Soares, Bernadette C. ;

Proietti, Fernando A. ;

Namen-Lopes, Sueli ;

Britomelo, Gustavo E. A. ;

Carneiro-Proietti, Anna Barbara F. .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2006, 142 (05) :811-815

[24] Ocular manifestations in adult T-cell leukemia/lymphoma [J].

Shibata, K ;

Shimamoto, Y ;

Nishimura, T ;

Okinami, S ;

Yamada, H ;

Miyahara, M .

ANNALS OF HEMATOLOGY, 1997, 74 (04) :163-168

[25] Survey of 1264 patients with orbital tumors and simulating lesions - The 2002 Montgomery Lecture, Part 1 [J].

Shields, JA ;

Shields, CL ;

Scartozzi, R .

OPHTHALMOLOGY, 2004, 111 (05) :997-1008

[26] DIAGNOSTIC-CRITERIA AND CLASSIFICATION OF CLINICAL SUBTYPES OF ADULT T-CELL LEUKEMIA-LYMPHOMA - A REPORT FROM THE LYMPHOMA-STUDY-GROUP (1984-87) [J].

SHIMOYAMA, M .

BRITISH JOURNAL OF HAEMATOLOGY, 1991, 79 (03) :428-437

[27] Human T-lymphotropic virus 1:: recent knowledge about an ancient infection [J].

Verdonck, Kristien ;

Gonzalez, Elsa ;

Van Dooren, Sonia ;

Vandamme, Anne-Mieke ;

Vanham, Guido ;

Gotuzzo, Eduardo .

LANCET INFECTIOUS DISEASES, 2007, 7 (04) :266-281

[28]

YAMAMOTO N, 1994, J NEURO-OPHTHALMOL, V14, P81

[29] Bilateral orbital tumor as initial presenting sign in human T-cell leukemia virus-1 associated adult T-cell leukemia/lymphoma [J].

Yoshikawa, T ;

Ogata, N ;

Takahashi, K ;

Mori, S ;

Uemura, Y ;

Matsumura, M .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2005, 140 (02) :327-329

← 1 2 3 →