Apolipoprotein E polymorphism in Saudis

被引：1

作者：

Al-Khedhairy, AA ^{[1
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia

来源：

MOLECULAR BIOLOGY REPORTS | 2004年 / 31卷 / 04期

关键词：

apolipoprotein E (apoE); polymorphism; genotype; Saudis;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apolipoprotein E (apoE) genotypes were determined in 165 Saudis. The prevalence of genotype, E3/E3, E3/E4 and E4/E4 was found to be 71, 27 and 2% respectively. The E3/E3 was the most prevalent genotype among the Saudis followed by E3/E4. However, other genotypes E2/E2, E2/E3 and E2/E4 were absent showing the absence of E2 allele in the test population. The high frequencies of the E3 allele (0.845) and E3/E3 genotype (0.71) and absence of E2 allele in Saudis under study are similar to those reported earlier for Native Americans, Mexican-Americans, Mayans, Cayapa, Mazatecan Indians and Mexican Mestizos populations.

引用

页码：257 / 260

页数：4

共 33 条

[1] Apolipoprotein E genotypes in a group of elderly subjects of Spanish descent living in Mexico City [J].

Castelli, P ;

Sosa, AL ;

Campillo, C ;

Nicolini, H ;

Cruz-Fuentes, C .

INTERNATIONAL PSYCHOGERIATRICS, 2002, 14 (03) :291-300

[2] Polymorphism of the apolipoprotein E gene and early carotid atherosclerosis defined by ultrasonography in asymptomatic adults [J].

Cattin, L ;

Fisicaro, M ;

Tonizzo, M ;

Valenti, M ;

Danek, GM ;

Fonda, M ;

DaCol, PG ;

Casagrande, S ;

Pincetti, E ;

Bovenzi, M ;

Baralle, F .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (01) :91-94

[3] APOLIPOPROTEIN-E, EPSILON-4 ALLELE AS A MAJOR RISK FACTOR FOR SPORADIC EARLY AND LATE-ONSET FORMS OF ALZHEIMERS-DISEASE - ANALYSIS OF THE 19Q13.2 CHROMOSOMAL REGION [J].

CHARTIERHARLIN, MC ;

PARFITT, M ;

LEGRAIN, S ;

PEREZTUR, J ;

BROUSSEAU, T ;

EVANS, A ;

BERR, C ;

VIDAL, O ;

ROQUES, P ;

GOURLET, V ;

FRUCHART, JC ;

DELACOURTE, A ;

ROSSOR, M ;

AMOUYEL, P .

HUMAN MOLECULAR GENETICS, 1994, 3 (04) :569-574

[4] THE STRUCTURE OF THE PRESENILIN-1 (S182) GENE AND IDENTIFICATION OF 6 NOVEL MUTATIONS IN EARLY-ONSET AD FAMILIES [J].

CLARK, RF ;

HUTTON, M ;

FULDNER, RA ;

FROELICH, S ;

KARRAN, E ;

TALBOT, C ;

CROOK, R ;

LENDON, C ;

PRIHAR, G ;

HE, C ;

KORENBLAT, K ;

MARTINEZ, A ;

WRAGG, M ;

BUSFIELD, F ;

BEHRENS, MI ;

MYERS, A ;

NORTON, J ;

MORRIS, J ;

MEHTA, N ;

PEARSON, C ;

LINCOLN, S ;

BAKER, M ;

DUFF, K ;

ZEHR, C ;

PEREZTUR, J ;

HOULDEN, H ;

RUIZ, A ;

OSSA, J ;

LOPERA, F ;

ARCOS, M ;

MADRIGAL, L ;

COLLINGE, J ;

HUMPHREYS, C ;

ASHWORTH, A ;

SARNER, S ;

FOX, N ;

HARVEY, R ;

KENNEDY, A ;

ROQUES, P ;

CLINE, RT ;

PHILLIPS, CA ;

VENTER, JC ;

FORSELL, L ;

AXELMAN, K ;

LILIUS, L ;

JOHNSTON, J ;

COWBURN, R ;

VIITANEN, M ;

WINBLAD, B ;

KOSIK, K .

NATURE GENETICS, 1995, 11 (02) :219-222

[5] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[6] SINGLE-DAY APOLIPOPROTEIN-E GENOTYPING [J].

CROOK, R ;

HARDY, J ;

DUFF, K .

JOURNAL OF NEUROSCIENCE METHODS, 1994, 53 (02) :125-127

[7]

EGENSPERGER R, 1995, ACTA NEUROPATHOL, V90, P257

[8] Apolipoprotein E genetic polymorphism, remnant lipoproteins, and nephropathy in type 2 diabetic patients [J].

Eto, M ;

Saito, M ;

Okada, M ;

Kume, Y ;

Kawasaki, F ;

Matsuda, M ;

Yoneda, M ;

Matsuki, M ;

Takigami, S ;

Kaku, K .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 40 (02) :243-251

[9]

Fan P, 1999, Hua Xi Yi Ke Da Xue Xue Bao, V30, P373

[10] Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease - A meta-analysis [J].

Farrer, LA ;

Cupples, LA ;

Haines, JL ;

Hyman, B ;

Kukull, WA ;

Mayeux, R ;

Myers, RH ;

PericakVance, MA ;

Risch, N ;

vanDuijn, CM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (16) :1349-1356

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