Bile acids: short and long term effects in the intestine

被引：108

作者：

Bajor, Antal ^{[1
]}

Gillberg, Per-Goran ^{[2
]}

Abrahamsson, Hasse ^{[1
]}

机构：

[1] Sahlgrens Univ Hosp, Dept Internal Med, S-41345 Gothenburg, Sweden

[2] Uppsala Univ, Dept Neurosci, Uppsala, Sweden

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 2010年 / 45卷 / 06期

关键词：

ALPHA-OST-BETA; IRRITABLE-BOWEL-SYNDROME; ORGANIC SOLUTE TRANSPORTER; BILIARY LIPID-COMPOSITION; FORMYL-PEPTIDE RECEPTORS; PLASMA DEOXYCHOLIC-ACID; CORONARY-HEART-DISEASE; COLONIC MOTOR FUNCTION; TUMOR-NECROSIS-FACTOR; CHRONIC DIARRHEA;

D O I：

10.3109/00365521003702734

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Bile acids have secretory, motility and antimicrobial effects in the intestine. In patients with bile acid malabsorption the amount of primary bile acids in the colon is increased compared to healthy controls. Deoxycholic acid is affecting the intestinal smooth muscle activity. Chenodeoxycholic acid has the highest potency to affect intestinal secretion. Litocholic acid has little effect in the lumen of intestine compared to both deoxycholic acid and chenodeoxycholic acid. There is no firm evidence that clinically relevant concentrations of bile acids induce colon cancer. Alterations in bile acid metabolism may be involved in the pathophysiology of constipation.

引用

页码：645 / 664

页数：20

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