Altered Regional Homogeneity in Patients With Congenital Blindness: A Resting-State Functional Magnetic Resonance Imaging Study

被引:4
作者
Hu, Jiong-Jiong [1 ]
Jiang, Nan [2 ,3 ]
Chen, Jun [4 ]
Ying, Ping [5 ]
Kang, Ming [5 ]
Xu, San-Hua [5 ]
Zou, Jie [5 ]
Wei, Hong [5 ]
Ling, Qian [5 ]
Shao, Yi [5 ]
机构
[1] Fudan Univ, Zhongshan Hosp, Dept Ophthalmol, Shanghai, Peoples R China
[2] Wenzhou Med Univ, Sch Optometry & Ophthalmol, Mol Neuropharmacol Lab, Wenzhou, Peoples R China
[3] Wenzhou Med Univ, Eye Hosp, Wenzhou, Peoples R China
[4] Jiangxi Univ Tradit Chinese Med, Nanchang, Jiangxi, Peoples R China
[5] Nanchang Univ, Affiliated Hosp 1, Dept Ophthalmol, Nanchang, Jiangxi, Peoples R China
关键词
congenital blindness; regional homogeneity; resting-state fMRI; anxiety; depression; SPONTANEOUS BRAIN ACTIVITY; SUPERIOR FRONTAL GYRUS; PREFRONTAL CORTEX; OCCIPITAL CORTEX; EYE FIELDS; CONNECTIVITY; PERCEPTION; SPECIALIZATION; DEPRESSION; PATTERNS;
D O I
10.3389/fpsyt.2022.925412
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
In patients with congenital blindness (CB), the lack of any visual experience may affect brain development resulting in functional, structural, or even psychological changes. Few studies to date have addressed or focused on the synchronicity of regional brain activity in patients with CB. Our study aimed to investigate regional brain activity in patients with CB in a resting state and try to explain the possible causes and effects of any anomalies. Twenty-three CB patients and 23 healthy control (HC) volunteers agreed to undergo resting state functional magnetic resonance imaging (fMRI) scans. After the fMRI data were preprocessed, regional homogeneity (ReHo) analysis was conducted to assess the differences in brain activity synchronicity between the two groups. Receiver operating characteristic (ROC) curve analysis was used to explore whether the brain areas with statistically significant ReHo differences have diagnostic and identification values for CB. All CB patients were also required to complete the Hospital Anxiety and Depression Scale (HADS) to evaluate their anxiety and depression levels. The results showed that in CB patients mean ReHo values were significantly lower than in HCs in the right orbital part of the middle frontal gyrus (MFGorb), bilateral middle occipital gyrus (MOG), and the right dorsolateral superior frontal gyrus (SFGdl), but significantly higher in the left paracentral lobule (PCL), right insula and bilateral thalamus. The ReHo value of MFGorb showed a negative linear correlation with both the anxiety score and the depression score of the HADS. ROC curve analysis revealed that the mean ReHo values which differed significantly between the groups have excellent diagnostic accuracy for CB (especially in the left PCL and right SFGdl regions). Patients with CB show abnormalities of ReHo values in several specific brain regions, suggesting potential regional structural changes, functional reorganization, or even psychological effects in these patients. FMRI ReHo analysis may find use as an objective method to confirm CB for medical or legal purposes.
引用
收藏
页数:11
相关论文
共 75 条
[1]   Patterns of Individual Variation in Visual Pathway Structure and Function in the Sighted and Blind [J].
Aguirre, Geoffrey K. ;
Datta, Ritobrato ;
Benson, Noah C. ;
Prasad, Sashank ;
Jacobson, Samuel G. ;
Cideciyan, Artur V. ;
Bridge, Holly ;
Watkins, Kate E. ;
Butt, Omar H. ;
Dain, Aleksandra S. ;
Brandes, Lauren ;
Gennatas, Efstathios D. .
PLOS ONE, 2016, 11 (11)
[2]  
Albohn DN, 2016, NEUROIMAGING PERSONALITY, SOCIAL COGNITION AND CHARACTER, P159, DOI 10.1016/B978-0-12-800935-2.00008-7
[3]   Imaging studies in congenital anophthalmia reveal preservation of brain architecture in 'visual' cortex [J].
Bridge, Holly ;
Cowey, Alan ;
Ragge, Nicola ;
Watkins, Kate .
BRAIN, 2009, 132 :3467-3480
[4]   Contingency awareness in human aversive conditioning involves the middle frontal gyrus [J].
Carter, RM ;
O'Doherty, JP ;
Seymour, B ;
Koch, C ;
Dolan, RJ .
NEUROIMAGE, 2006, 29 (03) :1007-1012
[5]   Neuroplasticity in adult human visual cortex [J].
Castaldi, Elisa ;
Lunghi, Claudia ;
Morrone, Maria Concetta .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2020, 112 :542-552
[6]   Congenital blindness affects diencephalic but not mesencephalic structures in the human brain [J].
Cecchetti, Luca ;
Ricciardi, Emiliano ;
Handjaras, Giacomo ;
Kupers, Ron ;
Ptito, Maurice ;
Pietrini, Pietro .
BRAIN STRUCTURE & FUNCTION, 2016, 221 (03) :1465-1480
[7]   Reduction of dorsolateral prefrontal cortex gray matter in late-life depression [J].
Chang, Cheng-Chen ;
Yu, Shun-Chieh ;
McQuoid, Douglas R. ;
Messer, Denise F. ;
Taylor, Warren D. ;
Singh, Kulpreet ;
Boyd, Brian D. ;
Krishnan, K. Ranga R. ;
MacFall, James R. ;
Steffens, David C. ;
Payne, Martha E. .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2011, 193 (01) :1-6
[8]  
Clark D.L., 2018, The Brain and Behavior: An Introduction to Behavioral Neuroanatomy, V4, DOI [10.1017/9781108164320, DOI 10.1017/9781108164320]
[9]   Functional specialization for auditory-spatial processing in the occipital cortex of congenitally blind humans [J].
Collignon, Olivier ;
Vandewalle, Gilles ;
Voss, Patrice ;
Albouy, Genevieve ;
Charbonneau, Genevieve ;
Lassonde, Maryse ;
Lepore, Franco .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (11) :4435-4440
[10]   Subcortical functional reorganization due to early blindness [J].
Coullon, Gaelle S. L. ;
Jiang, Fang ;
Fine, Ione ;
Watkins, Kate E. ;
Bridge, Holly .
JOURNAL OF NEUROPHYSIOLOGY, 2015, 113 (07) :2889-2899