Solvent-free microwave assisted synthesis of (E)-1-{3-[2-(9-Ethyl-9H-carbazol-3-yl)vinyl]benzofuran-2-yl}-2,2-dimethylpropan-1-ones and their antimicrobial activity

被引：8

作者：

Ashok, D. ^{[1
]}

Sidda, Ravi ^{[1
]}

Lakshmi, B. Vijaya ^{[1
]}

Ganesh, Arram ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2014年 / 84卷 / 11期

关键词：

microwave assisted synthesis; carbazole-3-carbaldehyde; carbazolylaryl prop-2-enones; carbazolylvinylbenzofurans; antimicrobial activity; CHALCONES; DERIVATIVES; BENZOFURAN;

D O I：

10.1134/S1070363214110280

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the solvent-free synthesis of (E)-1-{3-[2-(9-Ethyl-9H-carbazol-3-yl)vinyl]benzofuran-2-yl}-2,2-dimethylpropan-1-ones starting with 9-Ethyl-9H-carbazole-3-carbaldehyde under conventional and microwave irradiation methods. All products were characterised by IR, H-1 NMR, C-13 NMR, mass spectrometry, and elemental analysis. The compounds were tested in vitro for their antimicrobial activity.

引用

页码：2211 / 2217

页数：7

共 19 条

[1]

Ashok D, 2013, INDIAN J HETEROCY CH, V23, P11

[2] Solvent-free microwave-assisted synthesis of E-(1)-(6-benzoyl-3,5-dimethylfuro[3′,2′:4,5]benzo[b]furan-2-yl)-3-(aryl)-2-propen-1-ones and their antibacterial activity [J].

Ashok, D. ;

Sudershan, K. ;

Khalilullah, M. .

GREEN CHEMISTRY LETTERS AND REVIEWS, 2012, 5 (02) :121-125

[3] One-pot synthesis of novel spiro 2,3,7,8-tetrahydro-benzo[1,2-b:5,4-b′]-dipyran-4,6-dione and 2,3,8,9-tetrahydro-benzo[1,2-b:4,3-b′]dipyran-4,10-dione derivatives [J].

Ashok, D. ;

Shravani, D. .

TETRAHEDRON LETTERS, 2008, 49 (50) :7227-7229

[4] Synthesis of novel carbazole chalcones as radical scavenger, antimicrobial and cancer chemopreventive agents [J].

Bandgar, Babasaheb P. ;

Adsul, Laxman K. ;

Lonikar, Shrikant V. ;

Chavan, Hemant V. ;

Shringare, Sadanand N. ;

Patil, Sachin A. ;

Jalde, Shivkumar S. ;

Koti, Basawaraj A. ;

Dhole, Nagesh A. ;

Gacche, Rajesh N. ;

Shirfule, Amol .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 28 (03) :593-600

[5] Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity [J].

Bano, Sameena ;

Javed, Kalim ;

Ahmad, Shamim ;

Rathish, I. G. ;

Singh, Surender ;

Chaitanya, M. ;

Arunasree, K. M. ;

Alam, M. S. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 65 :51-59

[6]

Desai S. A., 2013, Journal of Applied Pharmaceutical Science, V3, P99

[7]

DUMAS J, 2005, Patent No. 2005014566

[8] Synthesis of Methoxy-substituted Chalcones and in vitro Evaluation of their Anticancer Potential [J].

Ethiraj, Kannatt Radhakrishnan ;

Aranjani, Jesil Mathew ;

Khan, Fazlur-Rahman Nawaz .

CHEMICAL BIOLOGY & DRUG DESIGN, 2013, 82 (06) :732-742

[9] Synthesis of potent antitumor and antiviral benzofuran derivatives [J].

Galal, Shadia A. ;

El-All, Amira S. Abd ;

Abdallah, Mohamed M. ;

El-Diwani, Hoda I. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (09) :2420-2428

[10] Hydroxychalcones as Potential Anti-Angiogenic Agent [J].

Karki, Radha ;

Kang, Youra ;

Kim, Chul Hoon ;

Kwak, Kyungsook ;

Kim, Jung-Ae ;

Lee, Eung-Seok .

BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 33 (09) :2925-2929

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