Staphylococcus aureus vaccine for orthopedic patients: An economic model and analysis

被引：24

作者：

Lee, Bruce Y. ^{[1
,2
,3
]}

Wiringa, Ann E. ^{[2
,3
]}

Bailey, Rachel R. ^{[2
,3
]}

Lewis, G. Jonathan ^{[2
,3
]}

Feura, Jared ^{[2
,3
]}

Muder, Robert R. ^{[4
]}

机构：

[1] Univ Pittsburgh, Publ Hlth Computat & Operat Res PHICOR, Sect Decis Sci & Clin Syst Modeling, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Biomed Informat, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Div Infect Dis, VA Pittsburgh Hlth Syst, Pittsburgh, PA 15213 USA

来源：

VACCINE | 2010年 / 28卷 / 12期

关键词：

Staphylococcus aureus; Vaccine; Orthopedic surgery; Economics; Computer simulation; POLYSACCHARIDE CONJUGATE VACCINE; QUALITY-OF-LIFE; PASSIVE-IMMUNIZATION; TOTAL HIP; MRSA; INFECTIONS; SURGERY; UTILITY; IMMUNOTHERAPY; ARTHROPLASTY;

D O I：

10.1016/j.vaccine.2009.12.075

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate the potential economic value of a Staphylococcus aureus vaccine for pre-operative orthopedic surgery patients, we developed an economic computer simulation model. At MRSA colonization rates as low as 1%, a $50 vaccine was cost-effective [<=$50,000 per quality-adjusted life year (QALY) saved] at vaccine efficacy >= 30%, and a $100 vaccine at vaccine efficacy >= 70%. High MASA prevalence (>= 25%) could justify a vaccine price as high as $1000. Our results suggest that a S. aureus vaccine for the pre-operative orthopedic population would be very cost-effective over a wide range of MASA prevalence and vaccine efficacies and costs. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2465 / 2471

页数：7

共 42 条

[31] Prospects for active and passive immunization against Staphylococcus aureus [J].

Shinefield, HR ;

Black, S .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2006, 25 (02) :167-168

[32]

SHINEFIELD HR, 2002, VACCINE S2, V24

[33] Methicillin-resistant Staphylococcus aureus in orthopaedic surgery [J].

Tai, CC ;

Nirvani, AA ;

Holmes, A ;

Hughes, SPF .

INTERNATIONAL ORTHOPAEDICS, 2004, 28 (01) :32-35

[34] One thousand health-related quality-of-life estimates [J].

Tengs, TO ;

Wallace, A .

MEDICAL CARE, 2000, 38 (06) :583-637

[35]

*THOMP HEALTHC INC, 2009, PDR RED BOOK 2009

[36] Recovery of gait after short-stay total hip arthroplasty [J].

van den Akker-Scheek, Inge ;

Stevens, Martin ;

Bulstra, Sjoerd K. ;

Groothoff, Johan W. ;

van Horn, Jim R. ;

Zijlstra, Wiebren .

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2007, 88 (03) :361-367

[37] Identification of the capsular polysaccharides in Staphylococcus aureus clinical isolates by PCR and agglutination tests [J].

Verdier, Isabelle ;

Durand, Geraldine ;

Bes, Michele ;

Taylor, Kimberly L. ;

Lina, Gerard ;

Vandenesch, Francois ;

Fattom, Ali I. ;

Etienne, Jerome .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (03) :725-729

[38]

Walley G, 2009, ACTA ORTHOP BELG, V75, P245

[39] Use of perioperative mupirocin to prevent methicillin-resistant Staphylococcus aureus (MRSA) orthopaedic surgical site infections [J].

Wilcox, MH ;

Hall, J ;

Pike, H ;

Templeton, PA ;

Fawley, WN ;

Parnell, P ;

Verity, P .

JOURNAL OF HOSPITAL INFECTION, 2003, 54 (03) :196-201

[40]

Wilmoth J., 2008, Human mortality database

← 1 2 3 4 5 →