Release of granzymes and chemokines in Thai patients with leptospirosis

被引：19
作者：
De Fost, M.
Chierakul, W.
Limpaiboon, R.
Dondorp, A.
White, N. J.
Van der Poll, T.
机构：
[1] Mahidol Univ, Fac Trop Med, Bangkok, Thailand
[2] Udon Thani Gen Hosp, Dept Med, Udon Thani, Thailand
[3] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Ctr Trop Med, Oxford OX3 9DU, England
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2007年 / 13卷 / 04期
基金：
英国惠康基金;
关键词：
cell-mediated immunity; chemokines; granzymes; host reponse; leptospirosis;
D O I：
10.1111/j.1469-0691.2006.01640.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The plasma concentrations of granzymes are considered to reflect the involvement of cytotoxic T-cells and natural killer cells in various disease states. Interferon (IFN)-gamma-inducible protein-10 (IP-10) and monokine induced by IFN-gamma (Mig) are members of the non-ELR CXC chemokine family that act on T-cells and natural killer cells. This study revealed that the plasma concentrations of granzyme B (but not granzyme A), IP-10 and Mig were higher in 44 Thai patients with definite or possible leptospirosis than in healthy blood donors. These data suggest that activation of cell-mediated immunity is part of the early host response to leptospirosis.
引用
收藏
页码：433 / 436
页数：4
相关论文
共 15 条
[1]   HOST IMMUNOLOGICAL MECHANISMS IN RESISTANCE OF MICE TO LEPTOSPIRAL INFECTIONS [J].
ADLER, B ;
FAINE, S .
INFECTION AND IMMUNITY, 1977, 17 (01) :67-72
[2]   Differential expression of interferon-γ and interferon-γ-inducing cytokines in Thai patients with scrub typhus or leptospirosis [J].
Chierakul, W ;
de Fost, M ;
Suputtamongkol, Y ;
Limpaiboon, R ;
Dondorp, A ;
White, NJ ;
van der Poll, T .
CLINICAL IMMUNOLOGY, 2004, 113 (02) :140-144
[3]   Activation of cytotoxic lymphocytes in patients with scrub typhus [J].
De Fost, M ;
Chierakul, W ;
Pimda, K ;
Dondorp, AM ;
White, NJ ;
Van der Poll, T .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2005, 72 (04) :465-467
[4]   Mig and IP-10: CXC chemokines that target lymphocytes [J].
Farber, JM .
JOURNAL OF LEUKOCYTE BIOLOGY, 1997, 61 (03) :246-257
[5]   Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan [J].
Juffermans, NP ;
Verbon, A ;
van Deventer, SJH ;
van Deutekom, H ;
Belisle, JT ;
Ellis, ME ;
Speelman, P ;
van der Poll, T .
INFECTION AND IMMUNITY, 1999, 67 (08) :4295-4297
[6]   Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo [J].
Kagi, D ;
Ledermann, B ;
Burki, K ;
Zinkernagel, RM ;
Hengartner, H .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :207-232
[7]   The CXC chemokines gamma interferon (IFN-γ)-inducible protein 10 and monokine induced by IFN-γ are released during severe melioidosis [J].
Lauw, FN ;
Simpson, AJH ;
Prins, JM ;
van Deventer, SJH ;
Chaowagul, W ;
White, NJ ;
van der Poll, T .
INFECTION AND IMMUNITY, 2000, 68 (07) :3888-3893
[8]   Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria [J].
Lauw, FN ;
Simpson, AJH ;
Hack, CE ;
Prins, JM ;
Wolbink, AM ;
van Deventer, SJH ;
Chaowagul, W ;
White, NJ ;
van der Poll, T .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (01) :206-213
[9]   Leptospirosis [J].
Levett, PN .
CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (02) :296-+
[10]   Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection [J].
Maxion, HK ;
Kelly, KA .
INFECTION AND IMMUNITY, 2002, 70 (03) :1538-1546
12