In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers

被引：129

作者：

Vargas, LY

Castelli, MV

Kouznetsov, VV

Urbina, JM

López, SN

Sortino, M

Enriz, RD

Ribas, JC

Zacchino, S ^{[1
]}

机构：

[1] Ind Univ Santander, Sch Chem, Lab Fine Organ Chem, Bucaramanga 678, Colombia

[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina

[3] Fac Quim, RA-5700 San Luis, Argentina

[4] Inst Microbiol Bioquim, Salamanca 37007, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 07期

关键词：

D O I：

10.1016/S0968-0896(02)00605-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-beta-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1531 / 1550

页数：20

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