Changes in cytokine production during and after normal pregnancy

被引:71
作者
Shimaoka, Y
Hidaka, Y
Tada, H
Nakamura, T
Mitsuda, N
Morimoto, Y
Murata, Y
Amino, N
机构
[1] Osaka Univ, Sch Med, Dept Lab Med, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Sch Med, Dept Obstet & Gynecol, Suita, Osaka 5650871, Japan
[3] Izumisano City Hosp, Osaka, Japan
[4] Aizenbashi Hosp, Osaka, Japan
来源
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2000年 / 44卷 / 03期
关键词
IFN-gamma; IL-2; IL-4; IL-10; Th1; Th2;
D O I
10.1111/j.8755-8920.2000.440303.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
PROBLEM: The systemic T helper 1/T helper 2 (Th1/Th2) cytokine balance during normal human pregnancy is controversial, and observations about the balance in the postpartum period have only been reported for up to 3 months. METHOD: Whole-blood, from 83 healthy pregnant women, 80 healthy postpartum women, and 31 healthy non-pregnant women was stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and the levels of cytokines in the supernatant were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: The production of all measured cytokines decreased during pregnancy, especially in the second trimester. After delivery, interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) increased from 2 to 11 months postpartum, and IL-4 increased from 6 to 11 months postpartum CONCLUSIONS: These data indicate that 1) decreases in production of both Th1- and Th2-type cytokines during pregnancy may be related to the pregnancy-induced amelioration of autoimmune diseases; 2) increases in production of both Th1- and Th2-type cytokines in the postpartum period may be related to the postpartum aggravation of autoimmune diseases.
引用
收藏
页码:143 / 147
页数:5
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