Impact of hematopoietic stem cell transplantation in patients with relapsed or refractory mantle cell lymphoma

被引：7

作者：

Yamasaki, Satoshi ^{[1
,2
]}

Chihara, Dai ^{[3
]}

Kim, Sung-Won ^{[4
]}

Izutsu, Koji ^{[5
]}

Iwato, Kouji ^{[6
,7
]}

Fukuda, Takahiro ^{[4
]}

Uchida, Naoyuki ^{[5
]}

Amano, Itsuto ^{[8
]}

Nakazawa, Hideyuki ^{[9
]}

Kuroda, Junya ^{[10
]}

Hashimoto, Hisako ^{[11
,12
]}

Ichinohe, Tatsuo ^{[13
]}

Kanda, Yoshinobu ^{[14
]}

Atsuta, Yoshiko ^{[15
,16
]}

Suzumiya, Junji ^{[17
]}

Suzuki, Ritsuro ^{[17
]}

机构：

[1] Natl Hosp Org Kyushu Med Ctr, Dept Hematol, Chuo Ku, 1-8-1 Jigyohama, Fukuoka, Fukuoka 8108563, Japan

[2] Natl Hosp Org Kyushu Med Ctr, Clin Res Inst, Chuo Ku, 1-8-1 Jigyohama, Fukuoka, Fukuoka 8108563, Japan

[3] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA

[4] Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[5] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Hematol, Tokyo, Japan

[6] Hiroshima Red Cross Hosp, Dept Hematol, Hiroshima, Japan

[7] Atom Bomb Survivors Hosp, Hiroshima, Japan

[8] Nara Med Univ Hosp, Dept Resp Allergy & Hematol, Nara, Japan

[9] Shinshu Univ, Div Hematol, Dept Internal Med, Sch Med, Matsumoto, Nagano, Japan

[10] Kyoto Prefectural Univ Med, Div Hematol & Oncol, Dept Med, Kyoto, Japan

[11] Kobe Gen Hosp, Dept Hematol & Cell therapy, Kobe, Hyogo, Japan

[12] Inst Biomed Res & Innovat, Kobe, Hyogo, Japan

[13] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, Hiroshima, Japan

[14] Jichi Med Univ, Saitama Med Ctr, Div Hematol, Saitama, Japan

[15] Nagoya Univ, Dept Healthcare Adm, Grad Sch Med, Nagoya, Aichi, Japan

[16] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

[17] Shimane Univ Hosp, Dept Hematol & Oncol, Izumo, Shimane, Japan

来源：

ANNALS OF HEMATOLOGY | 2018年 / 97卷 / 08期

关键词：

Mantle cell lymphoma; Autologous hematopoietic cell transplantation; Allogeneic hematopoietic cell transplantation relapsed or refractory; INTERNATIONAL BLOOD; MCL;

D O I：

10.1007/s00277-018-3318-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rituximab has been shown to improve outcomes in patients with B-cell lymphoma. However, patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) still have a poor prognosis, and the choice between high-dose therapy with autologous hematopoietic cell transplantation (HCT) and allogeneic HCT remains controversial in these patients. We retrospectively analyzed the risk factors for outcomes in 162 R/R MCL patients who received autologous (n = 111) or allogeneic (n = 51) HCT between 2004 and 2014. The median overall survival (OS) rates were 48 and 65 months in the autologous and allogeneic HCT groups, respectively (P = 0.20). Significant risk factors for overall survival in R/R MCL patients after autologous HCT were > 60 years of age at HCT (P = 0.017), higher score of HCT-specific comorbidity index at HCT (P = 0.033), and receiving MCEC (ranimustine + carboplatin + etoposide + cyclophosphamide) regimen (P = 0.017), while higher performance status at HCT (P = 0.011) and longer interval from diagnosis to HCT (P = 0.0054) were risk factors after allogeneic HCT. Strategies that carefully select R/R MCL patients for autologous HCT may allow the identification of individuals suitable for allogeneic HCT.

引用

页码：1445 / 1452

页数：8

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