Expression of vascular endothelial growth factor and the effects on bone remodeling during experimental tooth movement

被引：66

作者：

Kohno, S ^{[1
]}

Kaku, M ^{[1
]}

Tsutsui, K ^{[1
]}

Motokawa, M ^{[1
]}

Ohtani, J ^{[1
]}

Tenjo, K ^{[1
]}

Tohma, Y ^{[1
]}

Tokimasa, C ^{[1
]}

Fujita, T ^{[1
]}

Kawata, T ^{[1
]}

Tanne, K ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Orthodont, Fac Dent, Minami Ku, Hiroshima 7348553, Japan

来源：

JOURNAL OF DENTAL RESEARCH | 2003年 / 82卷 / 03期

关键词：

VEGF; osteoclast; osteoblast; bone remodeling; experimental tooth movement;

D O I：

10.1177/154405910308200306

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Vascular endothelial growth factor (VEGF) has an ability to induce functional osteoclasts as well as neovascularization. We recently reported that the number of osteoclasts was enhanced by the injection of recombinant human VEGF (rhVEGF) with the application of mechanical force for experimental tooth movement. In this study, the expression of VEGF was detected in osteoblasts on the tension side of the alveolar bone. Moreover, the rate of tooth movement was significantly increased in the rhVEGF injection groups compared with the controls. These results suggested that VEGF, highly expressed by mechanical stimuli, enhances the number of osteoclasts as a paritcrine factor, and that the amount of tooth movement is accelerated by both endogenous VEGF and injected rhVEGF.

引用

页码：177 / 182

页数：6

共 27 条

[1] Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1 [J].

Barleon, B ;

Sozzani, S ;

Zhou, D ;

Weich, HA ;

Mantovani, A ;

Marme, D .

BLOOD, 1996, 87 (08) :3336-3343

[2] VASCULAR-PERMEABILITY FACTOR (VASCULAR ENDOTHELIAL GROWTH-FACTOR) GENE IS EXPRESSED DIFFERENTIALLY IN NORMAL-TISSUES, MACROPHAGES, AND TUMORS [J].

BERSE, B ;

BROWN, LF ;

VANDEWATER, L ;

DVORAK, HF ;

SENGER, DR .

MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (02) :211-220

[3] The vascular endothelial growth factor receptor Flt-1 mediates biological activities - Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis [J].

Clauss, M ;

Weich, H ;

Breier, G ;

Knies, U ;

Rockl, W ;

Waltenberger, J ;

Risau, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) :17629-17634

[4] THE LOCAL USE OF VITAMIN-D TO INCREASE THE RATE OF ORTHODONTIC TOOTH MOVEMENT [J].

COLLINS, MK ;

SINCLAIR, PM .

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 1988, 94 (04) :278-284

[5] THE FMS-LIKE TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR [J].

DEVRIES, C ;

ESCOBEDO, JA ;

UENO, H ;

HOUCK, K ;

FERRARA, N ;

WILLIAMS, LT .

SCIENCE, 1992, 255 (5047) :989-991

[6] VASCULARIZATION OF THE MOUSE EMBRYO - A STUDY OF FLK-1, TEK, TIE, AND VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION DURING DEVELOPMENT [J].

DUMONT, DJ ;

FONG, GH ;

PURI, MC ;

GRADWOHL, G ;

ALITALO, K ;

BREITMAN, ML .

DEVELOPMENTAL DYNAMICS, 1995, 203 (01) :80-92

[7] VASCULAR-PERMEABILITY FACTOR VASCULAR ENDOTHELIAL GROWTH-FACTOR - AN IMPORTANT MEDIATOR OF ANGIOGENESIS IN MALIGNANCY AND INFLAMMATION [J].

DVORAK, HF ;

DETMAR, M ;

CLAFFEY, KP ;

NAGY, JA ;

VANDEWATER, L ;

SENGER, DR .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 107 (1-3) :233-235

[8] MACROPHAGE COLONY STIMULATING FACTOR RESTORES INVIVO BONE-RESORPTION IN THE OP/OP OSTEOPETROTIC MOUSE [J].

FELIX, R ;

CECCHINI, MG ;

FLEISCH, H .

ENDOCRINOLOGY, 1990, 127 (05) :2592-2594

[9] MOLECULAR AND BIOLOGICAL PROPERTIES OF THE VASCULAR ENDOTHELIAL GROWTH-FACTOR FAMILY OF PROTEINS [J].

FERRARA, N ;

HOUCK, K ;

JAKEMAN, L ;

LEUNG, DW .

ENDOCRINE REVIEWS, 1992, 13 (01) :18-32

[10] INDUCTION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION BY PROSTAGLANDIN E(2) AND E(1) IN OSTEOBLASTS [J].

HARADA, S ;

NAGY, JA ;

SULLIVAN, KA ;

THOMAS, KA ;

ENDO, N ;

RODAN, GA ;

RODAN, SB .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) :2490-2496

← 1 2 3 →