Expression of vascular endothelial growth factor and the effects on bone remodeling during experimental tooth movement

被引:65
作者
Kohno, S [1 ]
Kaku, M [1 ]
Tsutsui, K [1 ]
Motokawa, M [1 ]
Ohtani, J [1 ]
Tenjo, K [1 ]
Tohma, Y [1 ]
Tokimasa, C [1 ]
Fujita, T [1 ]
Kawata, T [1 ]
Tanne, K [1 ]
机构
[1] Hiroshima Univ, Dept Orthodont, Fac Dent, Minami Ku, Hiroshima 7348553, Japan
关键词
VEGF; osteoclast; osteoblast; bone remodeling; experimental tooth movement;
D O I
10.1177/154405910308200306
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Vascular endothelial growth factor (VEGF) has an ability to induce functional osteoclasts as well as neovascularization. We recently reported that the number of osteoclasts was enhanced by the injection of recombinant human VEGF (rhVEGF) with the application of mechanical force for experimental tooth movement. In this study, the expression of VEGF was detected in osteoblasts on the tension side of the alveolar bone. Moreover, the rate of tooth movement was significantly increased in the rhVEGF injection groups compared with the controls. These results suggested that VEGF, highly expressed by mechanical stimuli, enhances the number of osteoclasts as a paritcrine factor, and that the amount of tooth movement is accelerated by both endogenous VEGF and injected rhVEGF.
引用
收藏
页码:177 / 182
页数:6
相关论文
共 27 条
  • [1] Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    Barleon, B
    Sozzani, S
    Zhou, D
    Weich, HA
    Mantovani, A
    Marme, D
    [J]. BLOOD, 1996, 87 (08) : 3336 - 3343
  • [2] VASCULAR-PERMEABILITY FACTOR (VASCULAR ENDOTHELIAL GROWTH-FACTOR) GENE IS EXPRESSED DIFFERENTIALLY IN NORMAL-TISSUES, MACROPHAGES, AND TUMORS
    BERSE, B
    BROWN, LF
    VANDEWATER, L
    DVORAK, HF
    SENGER, DR
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (02) : 211 - 220
  • [3] The vascular endothelial growth factor receptor Flt-1 mediates biological activities - Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
    Clauss, M
    Weich, H
    Breier, G
    Knies, U
    Rockl, W
    Waltenberger, J
    Risau, W
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) : 17629 - 17634
  • [4] THE LOCAL USE OF VITAMIN-D TO INCREASE THE RATE OF ORTHODONTIC TOOTH MOVEMENT
    COLLINS, MK
    SINCLAIR, PM
    [J]. AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 1988, 94 (04) : 278 - 284
  • [5] THE FMS-LIKE TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR
    DEVRIES, C
    ESCOBEDO, JA
    UENO, H
    HOUCK, K
    FERRARA, N
    WILLIAMS, LT
    [J]. SCIENCE, 1992, 255 (5047) : 989 - 991
  • [6] VASCULARIZATION OF THE MOUSE EMBRYO - A STUDY OF FLK-1, TEK, TIE, AND VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION DURING DEVELOPMENT
    DUMONT, DJ
    FONG, GH
    PURI, MC
    GRADWOHL, G
    ALITALO, K
    BREITMAN, ML
    [J]. DEVELOPMENTAL DYNAMICS, 1995, 203 (01) : 80 - 92
  • [7] VASCULAR-PERMEABILITY FACTOR VASCULAR ENDOTHELIAL GROWTH-FACTOR - AN IMPORTANT MEDIATOR OF ANGIOGENESIS IN MALIGNANCY AND INFLAMMATION
    DVORAK, HF
    DETMAR, M
    CLAFFEY, KP
    NAGY, JA
    VANDEWATER, L
    SENGER, DR
    [J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 107 (1-3) : 233 - 235
  • [8] MACROPHAGE COLONY STIMULATING FACTOR RESTORES INVIVO BONE-RESORPTION IN THE OP/OP OSTEOPETROTIC MOUSE
    FELIX, R
    CECCHINI, MG
    FLEISCH, H
    [J]. ENDOCRINOLOGY, 1990, 127 (05) : 2592 - 2594
  • [9] MOLECULAR AND BIOLOGICAL PROPERTIES OF THE VASCULAR ENDOTHELIAL GROWTH-FACTOR FAMILY OF PROTEINS
    FERRARA, N
    HOUCK, K
    JAKEMAN, L
    LEUNG, DW
    [J]. ENDOCRINE REVIEWS, 1992, 13 (01) : 18 - 32
  • [10] INDUCTION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION BY PROSTAGLANDIN E(2) AND E(1) IN OSTEOBLASTS
    HARADA, S
    NAGY, JA
    SULLIVAN, KA
    THOMAS, KA
    ENDO, N
    RODAN, GA
    RODAN, SB
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) : 2490 - 2496