Identification and Clinical Relevance of Naturally Occurring Human CD8+HLA-DR+ Regulatory T Cells

被引：49

作者：

Arruvito, Lourdes ^{[1
]}

Payaslian, Florencia ^{[1
]}

Baz, Placida ^{[1
]}

Podhorzer, Ariel ^{[1
]}

Billordo, Ariel ^{[1
]}

Pandolfi, Julieta ^{[1
]}

Semeniuk, Guillermo ^{[2
]}

Arribalzaga, Eduardo ^{[3
]}

Fainboim, Leonardo ^{[1
]}

机构：

[1] Univ Buenos Aires, Inst Inmunol Genet & Metab, Hosp Clin Jose de San Martin, RA-1120 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Inst Invest Med Alfredo Lanari, Serv Neumonol, RA-1427 Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Hosp Clin Jose de San Martin, Div Cirugia Torac, RA-1120 Buenos Aires, DF, Argentina

来源：

JOURNAL OF IMMUNOLOGY | 2014年 / 193卷 / 09期

关键词：

TRANSCRIPTION FACTOR FOXP3; DENDRITIC CELLS; INTESTINAL INFLAMMATION; PERIPHERAL-BLOOD; TUMOR-IMMUNITY; LUNG-CANCER; LYMPHOCYTES; EXPRESSION; SUPPRESSION; POPULATION;

D O I：

10.4049/jimmunol.1401490

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The lack of responsiveness to self and non-self Ags is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. In this study, we show that CD8(+) T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8(+) regulatory T cell subset. Their suppressive effect appears to be cell-to-cell contact dependent and may involve CTLA-4 signaling between neighboring T cells. These regulatory T cells can be expanded in vitro and exhibit a suppressive capacity similar to that observed in ex vivo CD8(+)HLA-DR+ T cells. The high frequency of CD8(+)HLA-DR+ T cells that we detected in patients with non-small cell lung cancer deserves further work to confirm their putative suppressor effect within the tumor.

引用

页码：4469 / 4476

页数：8

共 38 条

[1] Human Regulatory CD8+ T Cell The Involvement of Cytokines [J].