The usefulness of post-genomics tools for characterization of the amine cross-talk in mammalian cells

被引:11
作者
Sanchez-Jimenez, F.
Montanez, R.
Correa-Fiz, F.
Rodriguez-Caso, C.
Urdiales, J. L.
Aldana, J. F.
Medina, M. A.
机构
[1] Univ Malaga, Dept Mol Biol & Biochem, E-29071 Malaga, Spain
[2] Univ Malaga, Dept Comp Languages & Comp Sci, E-29071 Malaga, Spain
关键词
cancer; histamine; inflammation; metabolic modelling; polyamine; protein modelling;
D O I
10.1042/BST0350381
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Evidence is growing in favour of a relationship between cancer and chronic inflammation, and particularly of the role of a polyamine and histamine metabolic interplay involved in these physiopathological problems, which are indeed highly complex biological systems. Decodification of the complex inter- and intra-cellular signalling mechanisms that control these effects is not an easy task, which must be helped by systems biology technologies, including new tools for location and integration of database-stored information and predictive mathematical models, as well as functional genomics and other experimental molecular approaches necessary for hypothesis validation. We review the state of the art and present our latest efforts in this area, focused on the amine metabolism field.
引用
收藏
页码:381 / 385
页数:5
相关论文
共 39 条
[1]   Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements [J].
Ai, WD ;
Liu, Y ;
Langlois, M ;
Wang, TC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (10) :8684-8693
[2]   Systemic mastocytosis [J].
Akin, C ;
Metcalfe, DD .
ANNUAL REVIEW OF MEDICINE, 2004, 55 :419-432
[3]  
Carlberg C, 2006, CRIT REV EUKAR GENE, V16, P1
[4]   Inflammation and cancer [J].
Coussens, LM ;
Werb, Z .
NATURE, 2002, 420 (6917) :860-867
[5]   Bioinformatics and cancer: An essential alliance [J].
Dopazo J. .
Clinical and Translational Oncology, 2006, 8 (6) :409-415
[6]   Histamine-cytokine connection in immunity and hematopoiesis [J].
Dy, M ;
Schneider, E .
CYTOKINE & GROWTH FACTOR REVIEWS, 2004, 15 (05) :393-410
[7]   The role of transglutaminase-2 and its substrates in human diseases [J].
Facchiano, F ;
Facchiano, A ;
Facchiano, AM .
FRONTIERS IN BIOSCIENCE, 2006, 11 :1758-1773
[8]   Histamine prevents polyamine accumulation in mouse C57.1 mast cell cultures [J].
Fajardo, I ;
Urdiales, JL ;
Paz, JC ;
Chavarría, T ;
Sánchez-Jiménez, F ;
Medina, MA .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (03) :768-773
[9]   Effects of phorbol ester and dexamethasone treatment on histidine decarboxylase and ornithine decarboxylase in basophilic cells [J].
Fajardo, I ;
Urdiales, JL ;
Medina, MA ;
Sanchez-Jimenez, F .
BIOCHEMICAL PHARMACOLOGY, 2001, 61 (09) :1101-1106
[10]  
FAJARDO I, 2001, COST ACTION 917 BIOG, P10