Neuropharmacology of memory consolidation and reconsolidation: Insights on central cholinergic mechanisms

被引：52
作者：
Blake, M. G. [1 ]
Krawczyk, M. C. [1 ]
Baratti, C. M. [1 ]
Boccia, M. M. [1 ]
机构：
[1] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Farmacol, Lab Neurofarmacol Proc Memoria, RA-1053 Buenos Aires, DF, Argentina
来源：
JOURNAL OF PHYSIOLOGY-PARIS | 2014年 / 108卷 / 4-6期
关键词：
Memory; Memory consolidation; Memory reconsolidation; Mice; Inhibitory avoidance; Acetylcholine; Alpha7 nicotinic receptors; Choline; Methyllycaconitine; Hippocampus; HIPPOCAMPAL NICOTINIC RECEPTORS; INHIBITORY AVOIDANCE-RESPONSE; CONDITIONED PLACE PREFERENCE; PROTEIN-SYNTHESIS; ALZHEIMERS-DISEASE; WORKING-MEMORY; ACETYLCHOLINE-RECEPTORS; REACTIVATED MEMORY; TRAUMATIC MEMORIES; IMPAIRS EXTINCTION;
D O I：
10.1016/j.jphysparis.2014.04.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Central cholinergic system is critically involved in all known memory processes. Endogenous acetylcholine release by cholinergic neurons is necessary for modulation of acquisition, encoding, consolidation, reconsolidation, extinction, retrieval and expression. Experiments from our laboratory are mainly focused on elucidating the mechanisms by which acetylcholine modulates memory processes. Blockade of hippocampal alpha-7-nicotinic receptors (alpha 7-nAChRs) with the antagonist methyllycaconitine impairs memory reconsolidation. However, the administration of a alpha 7-nAChR agonist (choline) produce a paradoxical modulation, causing memory enhancement in mice trained with a weak footshock, but memory impairment in animals trained with a strong footshock. All these effects are long-lasting, and depend on the age of the memory trace. This review summarizes and discusses some of our recent findings, particularly regarding the involvement of alpha 7-nAChRs on memory reconsolidation. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：286 / 291
页数：6
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