Neuropharmacology of memory consolidation and reconsolidation: Insights on central cholinergic mechanisms

被引：51
作者：
Blake, M. G. [1 ]
Krawczyk, M. C. [1 ]
Baratti, C. M. [1 ]
Boccia, M. M. [1 ]
机构：
[1] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Farmacol, Lab Neurofarmacol Proc Memoria, RA-1053 Buenos Aires, DF, Argentina
来源：
JOURNAL OF PHYSIOLOGY-PARIS | 2014年 / 108卷 / 4-6期
关键词：
Memory; Memory consolidation; Memory reconsolidation; Mice; Inhibitory avoidance; Acetylcholine; Alpha7 nicotinic receptors; Choline; Methyllycaconitine; Hippocampus; HIPPOCAMPAL NICOTINIC RECEPTORS; INHIBITORY AVOIDANCE-RESPONSE; CONDITIONED PLACE PREFERENCE; PROTEIN-SYNTHESIS; ALZHEIMERS-DISEASE; WORKING-MEMORY; ACETYLCHOLINE-RECEPTORS; REACTIVATED MEMORY; TRAUMATIC MEMORIES; IMPAIRS EXTINCTION;
D O I：
10.1016/j.jphysparis.2014.04.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Central cholinergic system is critically involved in all known memory processes. Endogenous acetylcholine release by cholinergic neurons is necessary for modulation of acquisition, encoding, consolidation, reconsolidation, extinction, retrieval and expression. Experiments from our laboratory are mainly focused on elucidating the mechanisms by which acetylcholine modulates memory processes. Blockade of hippocampal alpha-7-nicotinic receptors (alpha 7-nAChRs) with the antagonist methyllycaconitine impairs memory reconsolidation. However, the administration of a alpha 7-nAChR agonist (choline) produce a paradoxical modulation, causing memory enhancement in mice trained with a weak footshock, but memory impairment in animals trained with a strong footshock. All these effects are long-lasting, and depend on the age of the memory trace. This review summarizes and discusses some of our recent findings, particularly regarding the involvement of alpha 7-nAChRs on memory reconsolidation. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：286 / 291
页数：6
相关论文
共 83 条
  • [1] Mechanisms of memory stabilization and de-stabilization
    Alberini, C. M.
    Milekic, M. H.
    Tronel, S.
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (09) : 999 - 1008
  • [2] Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes?
    Alberini, CM
    [J]. TRENDS IN NEUROSCIENCES, 2005, 28 (01) : 51 - 56
  • [3] Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function
    Albuquerque, Edson X.
    Pereira, Edna F. R.
    Alkondon, Manickavasagom
    Rogers, Scott W.
    [J]. PHYSIOLOGICAL REVIEWS, 2009, 89 (01) : 73 - 120
  • [4] Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage
    Alejandro Caffaro, Pedro
    Daniel Suarez, Luis
    Gillermo Blake, Mariano
    Delorenzi, Alejandro
    [J]. NEUROBIOLOGY OF LEARNING AND MEMORY, 2012, 98 (03) : 235 - 245
  • [5] [Anonymous], 2007, The Mouse in Biomedical Research, DOI [10.1016/b978-012369454-6/50074-1, DOI 10.1016/B978-012369454-6/50074-1]
  • [6] Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation
    Baratti, C. M.
    Boccia, M. M.
    Blake, M. G.
    [J]. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2009, 42 (02) : 148 - 154
  • [7] Reactivated memory of an inhibitory avoidance response in mice is sensitive to a nitric oxide synthase inhibitor
    Baratti, Carlos M.
    Boccia, Mariano M.
    Blake, Mariano G.
    Acosta, Gabriela B.
    [J]. NEUROBIOLOGY OF LEARNING AND MEMORY, 2008, 89 (04) : 426 - 440
  • [8] Participation of hippocampal nicotinic receptors in acquisition, consolidation and retrieval of memory for one trial inhibitory avoidance in rats
    Barros, DM
    Ramirez, MR
    Dos Reis, EA
    Izquierdo, I
    [J]. NEUROSCIENCE, 2004, 126 (03) : 651 - 656
  • [9] Post-training and post-reactivation administration of amphetamine enhances morphine conditioned place preference
    Blaiss, Cory A.
    Janak, Patricia H.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2006, 171 (02) : 329 - 337
  • [10] Hippocampal α7-nicotinic cholinergic receptors modulate memory reconsolidation: A potential strategy for recovery from amnesia
    Blake, M. G.
    Boccia, M. M.
    Krawczyk, M. C.
    Baratti, C. M.
    [J]. NEUROBIOLOGY OF LEARNING AND MEMORY, 2013, 106 : 193 - 203
123456789