Epigallocatechingallate inhibits hepatocellular carcinoma progression in vitro

被引：0
作者：
Ai, Jianzhong [1 ]
Chen, Jihui [2 ]
Zhou, Qin [3 ]
Lv, Xiaoyan [2 ]
机构：
[1] Sichuan Univ, Dept Urol, Inst Urol, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Dermatol, 37 Guoxue Xiang, Chengdu 610041, Peoples R China
[3] Chongqing Med Univ, Div Mol Nephrol, Creat Training Ctr Undergrad, Minist Educ,Key Lab Lab Med Diagnost,Coll Lab Med, Chongqing 400016, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2017年 / 10卷 / 04期
基金：
中国国家自然科学基金;
关键词：
EGCG; HCC; progression; apoptosis; migration; GREEN TEA; METASTATIC CHARACTERISTICS; VIVO SELECTION; UNITED-STATES; CANCER CELLS; EGCG; OVEREXPRESSION; APOPTOSIS; SURVIVAL; INSIGHTS;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hepatocellular carcinoma (HCC) is one of the most mortal diseases, the metastasis and recurrence are the most important factors that influence the treatment efficacy of HCC. At present, the treatment for HCC was still not greatly improved. This study investigated the role of epigallocatechingallate (EGCG) in HCC progression in vitro using flow cytometry, western blot and BrdU assay. Our data indicated that EGCG promoted the HCC cell apoptosis and inhibited cell migration. Furthermore, EGCG did not inhibit the proliferation of HCCLM9 cells, a cell line of HCC with high metastatic potential, and it promoted HCCLM9 cell apoptosis through activating caspase-3. In summary, we concluded that EGCG can inhibit the progression of HCC in vitro, and it provided a foundation for the further study on the effective treatment of HCC.
引用
收藏
页码：6445 / 6452
页数：8
相关论文
共 25 条
[1]   FLNA and PGK1 are Two Potential Markers for Progression in Hepatocellular Carcinoma [J].
Ai, Jianzhong ;
Huang, Huizhe ;
Lv, Xiaoyan ;
Tang, Ziwei ;
Chen, Mianzhi ;
Chen, Tielin ;
Duan, Weiwei ;
Sun, Huan ;
Li, Qingwei ;
Tan, Ruizhi ;
Liu, Yuhang ;
Duan, Jingjing ;
Yang, Yang ;
Wei, Yuquan ;
Li, Yan ;
Zhou, Qin .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2011, 27 (3-4) :207-216
[2]   Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005 [J].
Altekruse, Sean F. ;
McGlynn, Katherine A. ;
Reichman, Marsha E. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (09) :1485-1491
[3]   Suppression of apoptosis by overexpression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage [J].
Cherbonnel-Lasserre, C ;
Dosanjh, MK .
BIOCHIMIE, 1997, 79 (9-10) :613-617
[4]   From proteomic analysis to clinical significance - Overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis [J].
Ding, SJ ;
Li, Y ;
Tan, YX ;
Jiang, MR ;
Tian, B ;
Liu, YK ;
Shao, XX ;
Ye, SL ;
Wu, JR ;
Zeng, R ;
Wang, HY ;
Tang, ZY ;
Xia, QC .
MOLECULAR & CELLULAR PROTEOMICS, 2004, 3 (01) :73-81
[5]   Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis [J].
El-Serag, Hashem B. ;
Rudolph, Lenhard .
GASTROENTEROLOGY, 2007, 132 (07) :2557-2576
[6]   Hepatocellular carcinoma: Recent trends in the United States [J].
El-Serag, HB .
GASTROENTEROLOGY, 2004, 127 (05) :S27-S34
[7]   How can (-)-epigallocatechin gallate from green tea prevent HIV-1 infection? Mechanistic insights from computational modeling and the implication for rational design of anti-HIV-1 entry inhibitors [J].
Hamza, A ;
Zhan, CG .
JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 110 (06) :2910-2917
[8]  
Hsieh TC, 2009, ANTICANCER RES, V29, P4025
[9]   Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway [J].
Hwang, Jin-Taek ;
Ha, Joohun ;
Park, In-Ja ;
Lee, Seong-Kyu ;
Baik, Haing Woon ;
Kim, Young Min ;
Park, Ock Jin .
CANCER LETTERS, 2007, 247 (01) :115-121
[10]   (-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells [J].
Larsen, Christine A. ;
Dashwood, Roderick H. .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2010, 501 (01) :52-57
123