Reduced expression of Rap1GAP as a prognostic biomarker for primary gastric cancer patients

被引：7

作者：

Zhao, Jingjing ^{[1
,2
]}

Mai, Cong ^{[3
]}

Weng, Desheng ^{[1
,2
]}

Chen, Changlong ^{[1
,2
]}

Zhou, Ziqi ^{[1
,2
]}

Liu, Yuan ^{[1
,2
]}

Zhou, Zhiwei ^{[1
,4
]}

Wang, Peng ^{[5
,6
]}

机构：

[1] Sun Yat Sen Univ, State Key Lab Oncol Southern China, Collaborat Innovat Ctr Canc Med, Canc Ctr, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Biotherapy, Canc Ctr, Guangzhou, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Affiliated Canc Hosp, Dept Abdominal Oncosurg, Guangzhou, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Canc Ctr, Guangzhou, Guangdong, Peoples R China

[5] Sun Yat Sen Univ, Dept Emergency Med, Sun Yat Sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China

[6] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Guangdong, Peoples R China

来源：

CANCER BIOMARKERS | 2018年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Rap1GAP; gastric cancer; prognosis; survival; PROMOTES INVASION; DOWN-REGULATION; CELL; SURVIVAL; 1P36; PROLIFERATION; PROTEIN; REGION;

D O I：

10.3233/CBM-170832

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: Rap1GAP, a member of the family of GTPase-activating proteins, is reported to be involved in cancer development and progression. OBJECTIVE: The study aimed to investigate the expression and prognostic value of Rap1GAP in gastric cancer patients. METHODS: Real-time quantitative polymerase chain reaction and western blotting were performed to examine Rap1GAP expression in tumorous and matched adjacent non-tumorous gastric tissues. Immunohistochemical staining was used to analyze Rap1GAP expression in 456 gastric cancer tissues. The correlation between Rap1GAP expression level and clinicopathological features as well as gastric cancer prognosis was analyzed. RESULTS: Rap1GAP expression was remarkably decreased in tumor tissues at mRNA (p = 0.012) and protein (p = 0.034) level. Clinicopathological analysis revealed that low Rap1GAP expression was significantly correlated with tumor size (p = 0.033), histological grade (p = 0.034), T classification (p = 0.012), N classification (p = 0.006) and clinical stage (p = 0.005). Kaplan-Meier survival analysis revealed the association between low Rap1GAP expression and poor survival in gastric cancer patients. Furthermore, multivariate Cox regression analysis showed that Rap1GAP expression was an independent prognostic factor (p = 0.02). CONCLUSION: Rap1GAP may play a significant role in gastric cancer progression and act as a valuable prognostic marker for gastric cancer.

引用

页码：375 / 384

页数：10

共 32 条

[11] Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product [J].