Theory of asymmetric organocatalysis of aldol and related reactions: Rationalizations and predictions

被引：435

作者：

Allemann, C ^{[1
]}

Gordillo, R ^{[1
]}

Clemente, FR ^{[1
]}

Cheong, PHY ^{[1
]}

Houk, KN ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2004年 / 37卷 / 08期

关键词：

D O I：

10.1021/ar0300524

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Computational studies have led to models to understand some classic and contemporary asymmetric reactions involving organo-catalysts. The Hajos-Parrish-Eder-Sauer-Wiechert reaction and intermolecular aldol reactions as well as Mannich reactions and oxyaminations catalyzed by proline and other amino acids, and Diels-Alder reactions catalyzed by MacMillan's chiral amine organocatalysts have been studied with density functional theory. Quantitative predictions for several new catalysts and reactions are provided.

引用

页码：558 / 569

页数：12

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