Exhaled breath analysis in the diagnosis of head and neck cancer

被引：15

作者：

Makitie, Antti A. ^{[1
,2
,3
,4
,5
]}

Almangush, Alhadi ^{[3
,6
,7
,8
]}

Youssef, Omar ^{[3
,6
]}

Metsala, Markus ^{[9
]}

Silen, Suvi ^{[1
,2
]}

Nixon, Iain J. ^{[10
]}

Haigentz, Missak, Jr. ^{[11
]}

Rodrigo, Juan P. ^{[12
]}

Saba, Nabil F. ^{[13
]}

Vander Poorten, Vincent ^{[14
,15
]}

Ferlito, Alfio ^{[16
]}

机构：

[1] Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[2] Helsinki Univ Hosp, Helsinki, Finland

[3] Univ Helsinki, Res Program Syst Oncol, Fac Med, Helsinki, Finland

[4] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, Stockholm, Sweden

[5] Karolinska Hosp, Stockholm, Sweden

[6] Univ Helsinki, Dept Pathol, Helsinki, Finland

[7] Univ Turku, Inst Biomed, Pathol, Turku, Finland

[8] Univ Misurata, Fac Dent, Misurata, Libya

[9] Univ Helsinki, Dept Chem, Helsinki, Finland

[10] Univ Edinburgh, NHS Lothian, Dept Otolaryngol Head & Neck Surg, Edinburgh, Midlothian, Scotland

[11] Atlantic Hlth Syst, Morristown Med Ctr, Dept Med, Div Hematol Oncol, Morristown, NJ USA

[12] Univ Oviedo, Hosp Univ Cent Asturias, Dept Otolaryngol, ISPA,IUOPA,CIBERONC, Oviedo, Spain

[13] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA

[14] Katholieke Univ Leuven, Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[15] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Oncol, Sect Head & Neck Oncol, Leuven, Belgium

[16] Int Head & Neck Sci Grp, Padua, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2020年 / 42卷 / 04期

关键词：

diagnosis; exhaled breath analysis; head and neck cancer; VOLATILE ORGANIC-COMPOUNDS; SQUAMOUS-CELL CARCINOMA; CONDENSATE PH; BIOMARKERS; HPV; CONSTITUENTS; COLLECTION; PREVENTION; DISEASE; MARKERS;

D O I：

10.1002/hed.26043

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Head and neck cancer (HNC) comprises a heterogeneous group of upper aerodigestive tract malignant neoplasms, the most frequent of which is squamous cell carcinoma. HNC forms the eighth most common cancer type and the incidence is increasing. However, survival has improved only moderately during the past decades. Currently, early diagnosis remains the mainstay for improving treatment outcomes in this patient population. Unfortunately, screening methods to allow early detection of HNC are not yet established. Therefore, many cases are still diagnosed at advanced stage, compromising outcomes. Exhaled breath analysis (EBA) is a diagnostic tool that has been recently introduced for many cancers. Breath analysis is non-invasive, cost-effective, time-saving, and can potentially be applied for cancer screening. Here, we provide a summary of the accumulated evidence on the feasibility of EBA in the diagnosis of HNC.

引用

页码：787 / 793

页数：7

共 59 条

[1] Mass-Spectrometry Analysis of Mixed-Breath, Isolated-Bronchial-Breath, and Gastric-Endoluminal-Air Volatile Fatty Acids in Esophagogastric Cancer [J].