Complement factor H-related proteins in IgA nephropathy-sometimes a gentle nudge does the trick

被引：8

作者：

Thurman, Joshua M. ^{[1
]}

Laskowski, Jennifer ^{[1
]}

机构：

[1] Univ Colorado, Dept Med, Sch Med, Anschutz Med Campus, Aurora, CO USA

来源：

KIDNEY INTERNATIONAL | 2017年 / 92卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.kint.2017.05.025

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Complement activation probably contributes to glomerular inflammation and damage in IgA nephropathy. In this issue, 2 groups report that levels of factor H-related protein 1 are elevated in patients with IgA nephropathy and correlate with disease progression. These studies provide new evidence that the complement cascade is important to the pathogenesis of this disease. These results also suggest that factor H-related protein 1 levels may be useful for identifying those patients at high risk of disease progression. Copyright (C) 2017, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

引用

页码：790 / 793

页数：5

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