JAK/STAT signaling in renal diseases

被引：100
作者：
Chuang, Peter Y. [1 ]
He, John C. [1 ,2 ,3 ]
机构：
[1] Mt Sinai Sch Med, Div Nephrol, Dept Med, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA
[3] James J Peters VA Med Ctr, York, NY USA
来源：
KIDNEY INTERNATIONAL | 2010年 / 78卷 / 03期
关键词：
DIABETIC-NEPHROPATHY; STAT3; PROLIFERATION; TRANSDUCER; ACTIVATOR; PATHWAY; INJURY;
D O I：
10.1038/ki.2010.158
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling. Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model. Kidney International (2010) 78, 231-234. doi: 10.1038/ki.2010.158
引用
收藏
页码：231 / 234
页数：4
相关论文
共 10 条
  • [1] Enhanced Expression of Janus Kinase-Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy
    Berthier, Celine C.
    Zhang, Hongyru
    Schin, MaryLee
    Henger, Anna
    Nelson, Robert G.
    Yee, Berne
    Boucherot, Anissa
    Neusser, Matthias A.
    Cohen, Clemens D.
    Carter-Su, Christin
    Argetsinger, Lawrence S.
    Rastaldi, Maria P.
    Brosius, Frank C.
    Kretzler, Matthias
    [J]. DIABETES, 2009, 58 (02) : 469 - 477
  • [2] Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways
    He, JCJ
    Husain, M
    Sunamoto, M
    D'Agati, VD
    Klotman, ME
    Iyengar, R
    Klotman, PE
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (05) : 643 - 651
  • [3] Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction
    Kuratsune, Masatoshi
    Masaki, Takao
    Hirai, Takayuki
    Kiribayashi, Kei
    Yokoyama, Yukio
    Arakawa, Tetsuji
    Yorioka, Noriaki
    Kohno, Nobuoki
    [J]. NEPHROLOGY, 2007, 12 (06) : 565 - 571
  • [4] Inhibition of JAK/STAT signaling ameliorates mice experimental nephrotic syndrome
    Li, Rong
    Yang, Niansheng
    Zhang, Lili
    Huang, Yuefang
    Zhang, Rui
    Wang, Fang
    Luo, Mingqian
    Liang, Yingjie
    Yu, Xueqing
    [J]. AMERICAN JOURNAL OF NEPHROLOGY, 2007, 27 (06) : 580 - 589
  • [5] Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy
    Lu, Ting-Chi
    Wang, Zhao-Hui
    Feng, Xiaobei
    Chuang, Peter Y.
    Fang, Wei
    Shen, Yuhong
    Levy, David E.
    Xiong, Huabao
    Chen, Nan
    He, John Cijiang
    [J]. KIDNEY INTERNATIONAL, 2009, 76 (01) : 63 - 71
  • [6] Role of the JAK/STAT signaling pathway in diabetic nephropathy
    Marrero, MB
    Banes-Berceli, AK
    Stern, DM
    Eaton, DC
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2006, 290 (04) : F762 - F768
  • [7] IL-6/IL-6R axis plays a critical role in acute kidney injury
    Nechemia-Arbely, Yael
    Barkan, Daniel
    Pizov, Galina
    Shriki, Anat
    Rose-John, Stefan
    Galun, Eithan
    Axelrod, Jonathan H.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (06): : 1106 - 1115
  • [8] A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
    Pang, Maoyin
    Ma, Li
    Gong, Rujun
    Tolbert, Evelyn
    Mao, Haiping
    Ponnusamy, Murugavel
    Chin, Y. Eugene
    Yan, Haidong
    Dworkin, Lance D.
    Zhuang, Shougang
    [J]. KIDNEY INTERNATIONAL, 2010, 78 (03) : 257 - 268
  • [9] Gas6 induces mesangial cell proliferation via latent transcription factor STAT3
    Yanagita, M
    Arai, H
    Nakano, T
    Ohashi, K
    Mizuno, K
    Fukatsu, A
    Doi, T
    Kita, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (45) : 42364 - 42369
  • [10] Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat
    Yang, Niansheng
    Luo, Mingqian
    Li, Rong
    Huang, Yuefang
    Zhang, Rui
    Wu, Qingqing
    Wang, Fang
    Li, Youji
    Yu, Xueqing
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (01) : 91 - 100
1