JAK/STAT signaling in renal diseases

被引：105
作者：
Chuang, Peter Y. [1 ]
He, John C. [1 ,2 ,3 ]
机构：
[1] Mt Sinai Sch Med, Div Nephrol, Dept Med, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA
[3] James J Peters VA Med Ctr, York, NY USA
来源：
KIDNEY INTERNATIONAL | 2010年 / 78卷 / 03期
关键词：
DIABETIC-NEPHROPATHY; STAT3; PROLIFERATION; TRANSDUCER; ACTIVATOR; PATHWAY; INJURY;
D O I：
10.1038/ki.2010.158
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling. Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model. Kidney International (2010) 78, 231-234. doi: 10.1038/ki.2010.158
引用
收藏
页码：231 / 234
页数：4
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