TaBr5-catalyzed Biginelli reaction:: one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions

被引：102
作者：
Ahmed, Naseem [1 ]
van Lier, Johan E. [1 ]
机构：
[1] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med Nucl & Radiobiol, Sherbrooke, PQ J1H 5N4, Canada
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 31期
基金：
加拿大健康研究院;
关键词：
TaBr5-catalyzed Biginelli reaction; solvent-free conditions; 3,4-dihydropyrirnidin-2-(1H)-ones/thiones;
D O I：
10.1016/j.tetlet.2007.06.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient TaBr5 (5-10 mol %)-catalyzed Biginelli reaction under solvent-free conditions for one-pot syntheses of 3,4-dilhydropyrimidin-2-(] H)-ones (DHPMs) and their thione analogs is reported. The catalyst is stable at room temperature and employed under mild and environmentally friendly conditions. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5407 / 5409
页数：3
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