The causes and consequences of random and non-random X chromosome inactivation in humans

被引：108

作者：

Brown, CJ ^{[1
]}

Robinson, WP ^{[1
]}

机构：

[1] Univ British Columbia, Dept Med Genet, Vancouver, BC V6T 1Z3, Canada

来源：

CLINICAL GENETICS | 2000年 / 58卷 / 05期

关键词：

embryonic stem cells; X chromosome; Xist gene;

D O I：

10.1034/j.1399-0004.2000.580504.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

X chromosome (X) inactivation is a remarkable biological process including the choice and cis-limited inactivation of one X, as well as the stable maintenance of this silencing by epigenetic chromatin alterations. The process results in females generally being mosaic for two populations of cells - one with each parental X active. In this review, we discuss recent advances in our understanding of how inactivation works, as well as the causes and clinical implications of deviations from random inactivation.

引用

页码：353 / 363

页数：11

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