Bisphenol A and Hormone-Associated Cancers: Current Progress and Perspectives

被引：158

作者：

Gao, Hui ^{[1
]}

Yang, Bao-Jun ^{[1
]}

Li, Nan ^{[2
]}

Feng, Li-Min ^{[1
]}

Shi, Xiao-Yu ^{[1
]}

Zhao, Wei-Hong ^{[1
]}

Liu, Si-Jin ^{[3
]}

机构：

[1] Capital Med Univ, Dept Obstet & Gynecol, Beijing TianTan Hosp, Beijing 100050, Peoples R China

[2] CAMS, Canc Inst & Hosp, Dept Gynecol, Beijing 100021, Peoples R China

[3] Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China

来源：

MEDICINE | 2015年 / 94卷 / 01期

关键词：

ESTROGEN-RECEPTOR-ALPHA; EPITHELIAL OVARIAN-CANCER; ENDOCRINE DISRUPTING CHEMICALS; ANDROGEN DEPRIVATION THERAPY; BREAST-CANCER; PROSTATE-CANCER; REPLACEMENT THERAPY; IN-VITRO; MAMMARY-GLAND; NEONATAL EXPOSURE;

D O I：

10.1097/MD.0000000000000211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bisphenol A (BPA), a carbon-based synthetic compound, exhibits hormone-like properties and is present ubiquitously in the environment and in human tissues due to its widespread use and biological accumulation. BPA can mimic estrogen to interact with estrogen receptors alpha and beta, leading to changes in cell proliferation, apoptosis, or migration and thereby, contributing to cancer development and progression. At the genetic level, BPA has been shown to be involved in multiple oncogenic signaling pathways, such as the STAT3, MAPK, and PI3K/AKT pathways. Moreover, BPA may also interact with other steroid receptors (such as androgen receptor) and plays a role in prostate cancer development. This review summarizes the current literature regarding human exposure to BPA, the endocrine-disrupting effects of BPA, and the role of BPA in hormone-associated cancers of the breast, ovary, and prostate.

引用

页数：8

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