Repeated Stereotactic Body Radiotherapy for Lung Malignancies: Toxicity Can Be Reduced by Sparing Lung Irradiation

被引：2

作者：

Watanabe, Shou ^{[1
]}

Yamazaki, Hideya ^{[1
,2
]}

Kimoto, Takyua ^{[1
,2
]}

Suzuki, Gen ^{[1
,2
]}

Yamada, Kei ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Radiol, Kyoto, Japan

[2] Soseikai Clin, CyberKnife Ctr, Kyoto, Japan

来源：

ANTICANCER RESEARCH | 2022年 / 42卷 / 05期

关键词：

Stereotactic body radiotherapy; primary lung cancer; oligometastasis; re-irradiation; radiation pneumonitis; RADIATION-THERAPY; ABLATIVE RADIOTHERAPY; REIRRADIATION; CANCER; REGISTRATION; OUTCOMES; TUMORS; SBRT;

D O I：

10.21873/anticanres.15748

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Evidence on the use of repeated stereotactic body radiotherapy (SBRT) is limited. We investigated the efficacy of repeated SBRT and predictors of lung toxicity. Patients and Methods: We reviewed 20 patients (27 lesions) with primary or metastatic lung cancer who underwent repeated SBRT with CyberKnife (R). We generated a composite plan for dosimetric analysis based on equivalent doses in 2.0-Gy fractions (alpha/beta=3). Predictors of Grade 2+ radiation pneumonitis ( RP) were examined. Results: The median follow-up duration was 18.0 months. The 1-year and 2-year local control were both 95.2%. Five patients ( 25%) developed Grade 2+ RP, including a Grade 5 RP. The Grade 2+ RP group showed higher composite mean lung dose (MLD) and lower lung volumes spared from 5-20 Gy (VS5-VS20). Conclusion: Repeated SBRT with CyberKnife (R) showed favorable local control, but a high rate of Grade 2+ RP. Accumulated MLD and VS5-VS20 may predict RP.

引用

页码：2701 / 2709

页数：9

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