Sulphotransferases acting on mucin-type oligosaccharides

被引：80

作者：

Brockhausen, I ^{[1
]}

机构：

[1] Queens Univ, Dept Med, Kingston, ON, Canada

[2] Queens Univ, Dept Biochem, Kingston, ON, Canada

[3] Queens Univ, Human Mobil Res Ctr, Kingston, ON, Canada

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷

关键词：

biosynthesis of glycoproteins; inflammation; O-glycan; mucin; sulphotransferase;

D O I：

10.1042/BST0310318

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act on mucin-type substrates in vitro, it is still difficult to determine exactly which enzymes are responsible for mucin sulphation in vivo. Sulphotransferases play a critical role in determining the chemical, physical and biological properties of mucins. Several of these enzymes have been shown to differ in expression and activity in cancer and inflammation.

引用

页码：318 / 325

页数：8

共 104 条

[51]

INOUE H, 1986, J BIOL CHEM, V261, P4460

[52]

IRIMURA T, 1991, CANCER RES, V51, P5728

[53] Conserved structural motifs in the sulfotransferase family [J].